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Helicobacter pylori Eradication Regressed Gastric Hyperplastic Polyp: A Randomized Controlled Trial

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Abstract

Background

Helicobacter pylori infection and hyperplastic polyp are known to have strong connections, but there are not enough randomized controlled trial data.

Aims

To evaluate the effect of H. pylori eradication on gastric hyperplastic polyp.

Method

This is an open-labeled, single-center, randomized controlled trial. Patients with hyperplastic polyp and current infection of H. pylori were randomly assigned to eradication or non-eradication groups. All participants underwent follow-up endoscopy to investigate the regression of gastric polyps. Gastric polyp regression was defined as the disappearance of polyps or a reduction of more than 50% in size.

Results

Thirty-two patients were randomized to eradication (n = 17) and non-eradication groups (n = 15). Final included patients were 14 in eradication group and 13 in non-eradication group. All patients showed polyp regression in eradication group, whereas no regression was observed in non-eradication group (P < 0.001). Disappearance of polyp (n = 7) and decrease in size (n = 7) were observed in eradication group. In non-eradication group, no change (n = 5), increase of size (n = 5), and increase of number (n = 3) were observed. Mean regression time was 6.8 months, and disappearance time was 9.8 months. In non-eradication group, hyperglycemia was noted in 50% of progression group but not noted in no change group (P = 0.057).

Conclusions

H. pylori eradication induced regression of hyperplastic polyp, and persistent H. pylori infection was related to progression of gastric polyp.

Clinical Trial Registration

ClinicalTrials.gov ID: NCT03065868

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Funding

This study was supported by a grand from Korean Colleague of Helicobacter and Upper Gastrointestinal Research (2015), Korea.

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Authors and Affiliations

  1. Department of Gastroenterology, Kyungpook National University Hospital Chilgok, School of Medicine, Kyungpook National University, 807 Hoguk-ro, Buk-gu, Daegu, 41404, Korea

    Su Youn Nam, Sang Won Lee, Seong Woo Jeon, Yong Hwan Kwon & Hyun Seok Lee

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  1. Su Youn Nam
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  2. Sang Won Lee
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  3. Seong Woo Jeon
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  4. Yong Hwan Kwon
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  5. Hyun Seok Lee
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Contributions

SY Nam contributed to the study design. SY Nam, SY Lee, SW Jeon, YH Kwon, and HS Lee contributed to the acquisition of data, implementation and supervision of the study. SY Nam and SW Lee contributed to the assembly of data. SY Nam and SW Lee analyzed the data. SY Nam took the responsibility for the accuracy of the data analysis and had full access to the data in the study. All authors participated in the writing of the manuscript and approved the final version of the manuscript.

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Correspondence to Su Youn Nam.

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Nam, S.Y., Lee, S.W., Jeon, S.W. et al. Helicobacter pylori Eradication Regressed Gastric Hyperplastic Polyp: A Randomized Controlled Trial. Dig Dis Sci 65, 3652–3659 (2020). https://doi.org/10.1007/s10620-020-06065-0

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  • DOI: https://doi.org/10.1007/s10620-020-06065-0

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