Abstract
Background
The Veterans Health Administration (VHA) provides care to the one of the largest cohorts of patients with advanced liver disease (ALD) in the USA.
Aims
We performed a national survey to assess system-wide strengths and barriers to care for Veterans with ALD in this national integrated healthcare setting.
Methods
A 52-item survey was developed to assess access and barriers to care in Veterans with ALD. The survey was distributed to all VHA medical centers in 2015. Results were analyzed using descriptive statistics.
Results
One hundred and fifty-three sites responded to this survey. Multidisciplinary services were available on-site at > 80% of sites. Ninety-five percent of sites had mental health and addictions treatment available, with 14% co-locating these services within the liver clinic. Few sites (< 25%) provided pharmacologic treatment for alcohol use disorder in primary care or hepatology settings. Seventy-two percent of sites reported at least one barrier to liver-related care. Of the sites reporting at least one barrier, 53% reported barriers to liver transplant referral, citing complex processes and lack of staff/resources to coordinate referrals. Palliative care was widely available, but 61% of sites reported referring < 25% of their patients with ALD for palliative services.
Conclusion
Multidisciplinary services for Veterans with ALD are widely available at VHA sites, though barriers to optimal care remain. Opportunities for improvement include the expansion of providers with hepatology expertise, integrating pharmacotherapy for alcohol use disorder into hepatology and primary care, streamlining the transplant referral process, and expanding palliative care referrals for patients with ALD.
Similar content being viewed by others
References
Schuppan D, Afdhal NH. Liver cirrhosis. Lancet. 2008;. https://doi.org/10.1016/s0140-6736(08)60383-9.
Alberti A, Chemello L, Benvegnù L. Natural history of hepatitis C. J Hepatol. 1999;31(Suppl 1):17–24.
Ikeda K, Saitoh S, Suzuki Y, et al. Disease progression and hepatocellular carcinogenesis in patients with chronic viral hepatitis: a prospective observation of 2215 patients. J Hepatol. 1998;28:930–938. https://doi.org/10.1016/S0168-8278(98)80339-5.
Backus LI, Belperio PS, Loomis TP, Yip GH, Mole LA. Hepatitis C virus screening and prevalence among US Veterans in Department of Veterans Affairs Care. JAMA Intern Med. 2013;173:1549–1552. https://doi.org/10.1001/jamainternmed.2013.8133.
Belperio PS, Chartier M, Gonzalez RI, et al. Hepatitis C Care in the Department of Veterans Affairs: building a foundation for success. Infect Dis Clin North Am. 2018;32:281–292. https://doi.org/10.1016/j.idc.2018.02.011.
Personal Communication, Dr. Maggie Chartier. HIV, Hepatitis, and Related Conditions Program Office; Department of Veterans Affairs. 2016.
Beste LA, Leipertz SL, Green PK, Dominitz JA, Ross D, Ioannou GN. Trends in burden of cirrhosis and hepatocellular carcinoma by underlying liver disease in US Veterans, 2001–2013. Gastroenterology. 2015;149:1471–1482. https://doi.org/10.1053/j.gastro.2015.07.056.
Xu J. Trends in liver cancer mortality among adults aged 25 and over in the United States, 2000–2016. NCHS Data Brief, no 314. Hyattsville, MD: National Center for Health Statistics. 2018. https://www.cdc.gov/nchs/data/databriefs/db314_table.pdf#1. Accessed February 11, 2019.
RURAL VETERANS—Office of Rural Health. https://www.ruralhealth.va.gov/aboutus/ruralvets.asp. Accessed May 9, 2019.
Russo MW, Koteish AA, Fuchs M, Reddy KG, Fix OK. Workforce in hepatology: update and a critical need for more information. Hepatology. 2017;65:336–340. https://doi.org/10.1002/hep.28810.
Beste LA, Glorioso TJ, Ho PM, et al. Telemedicine specialty support promotes hepatitis C treatment by primary care providers in the Department of Veterans Affairs. Am J Med. 2017;. https://doi.org/10.1016/j.amjmed.2016.11.019.
Su GL, Glass L, Tapper EB, Van T, Waljee AK, Sales AE. Virtual consultations through the veterans administration SCAN-ECHO project improves survival for veterans with liver disease. Hepatology. 2018;68:2317–2324. https://doi.org/10.1002/hep.30074.
Davis GL, Albright JE, Cook SF, Rosenberg DM. Projecting future complications of chronic hepatitis C in the United States. Liver Transpl. 2003;9:331–338. https://doi.org/10.1053/jlts.2003.50073.
Stein E, Cruz-Lemini M, Altamirano J, et al. Heavy daily alcohol intake at the population level predicts the weight of alcohol in cirrhosis burden worldwide. J Hepatol. 2016;65:998–1005. https://doi.org/10.1016/j.jhep.2016.06.018.
Younossi ZM, Koenig AB, Abdelatif D, Fazel Y, Henry L, Wymer M. Global epidemiology of nonalcoholic fatty liver disease—meta-analytic assessment of prevalence, incidence, and outcomes. Hepatology. 2016;64:73–84. https://doi.org/10.1002/hep.28431.
El-Serag HB, Kunik M, Richardson P, Rabeneck L. Psychiatric disorders among veterans with hepatitis C infection. Gastroenterology. 2002;123:476–482.
Patel K, Maguire E, Chartier M, Akpan I, Rogal S. Integrating care for patients with chronic liver disease and mental health and substance use disorders. Fed Pract. 2018;35:S14–S23.
Knott A, Dieperink E, Willenbring ML, et al. Integrated psychiatric/medical care in a chronic hepatitis C clinic: affect on antiviral treatment evaluation and outcomes. Am J Gastroenterol. 2006;101:2254–2262.
Groessl EJ, Sklar M, Cheung RC, Brau N, Ho SB. Increasing antiviral treatment through integrated hepatitis C care: a randomized multicenter trial. Contemp Clin Trials. 2013;35:97–107. https://doi.org/10.1016/j.cct.2013.05.002.
Ho SB, Bräu N, Cheung R, et al. Integrated care increases treatment and improves outcomes of patients with chronic hepatitis C virus infection and psychiatric illness or substance abuse. Clin Gastroenterol Hepatol. 2015;. https://doi.org/10.1016/j.cgh.2015.02.022.
Fireman M, Indest DW, Blackwell A, Whitehead AJ, Hauser P. Addressing tri-morbidity (hepatitis C, psychiatric disorders, and substance use): the importance of routine mental health screening as a component of a comanagement model of care. Clin Infect Dis. 2005;40:S286–S291. https://doi.org/10.1086/427442.
Lehman CL, Cheung RC. Depression, anxiety, post-traumatic stress, and alcohol-related problems among veterans with chronic hepatitis C. Am J Gastroenterol. 2002;97:2640–2646. https://doi.org/10.1111/j.1572-0241.2002.06042.x.
Cohen E, Feinn R, Arias A, Kranzler HR. Alcohol treatment utilization: findings from the National Epidemiologic Survey on Alcohol and Related Conditions. Drug Alcohol Depend. 2007;. https://doi.org/10.1016/j.drugalcdep.2006.06.008.
Madan A, Barth KS, Balliet WE, et al. Chronic pain among liver transplant candidates. Prog Transpl. 2012;22:379–384.
Bianchi G, Marchesini G, Nicolino F, et al. Psychological status and depression in patients with liver cirrhosis. Dig Liver Dis. 2005;37:593–600. https://doi.org/10.1016/j.dld.2005.01.020.
Marchesini G, Bianchi G, Amodio P, et al. Factors associated with poor health-related quality of life of patients with cirrhosis. Gastroenterology. 2001;120:170–178. https://doi.org/10.1053/gast.2001.21193.
Poonja Z, Brisebois A, Van Zanten SV, Tandon P, Meeberg G, Karvellas CJ. Patients with cirrhosis and denied liver transplants rarely receive adequate palliative care or appropriate management. Clin Gastroenterol Hepatol. 2014;12:692–698. https://doi.org/10.1016/j.cgh.2013.08.027.
Kathpalia P, Smith A, Lai JC. Underutilization of palliative care services in the liver transplant population. World J Transpl. 2016;6:594. https://doi.org/10.5500/wjt.v6.i3.594.
Rush B, Walley KR, Celi LA, Rajoriya N, Brahmania M. Palliative care access for hospitalized patients with end-stage liver disease across the United States. Hepatology. 2017;66(5):1585–1591. https://doi.org/10.1002/hep.29297.
Patel AA, Walling AM, May FP, Saab S, Wenger N. Palliative care and health care utilization for patients with end-stage liver disease at the end of life. Clin Gastroenterol Hepatol. 2017;15:1612–1619. https://doi.org/10.1016/j.cgh.2017.01.030.
Walling AM, Asch SM, Lorenz KA, Wenger NS. Impact of consideration of transplantation on end-of-life care for patients during a terminal hospitalization. Transplantation. 2013;95:641–646. https://doi.org/10.1097/TP.0b013e318277f238.
Temel JS, Greer JA, Muzikansky A. Early palliative care for patients with metastatic non-small-cell lung cancer. New Engl J Med. 2010;363:733–742.
Funding
This study was supported by the VHA’s HIV, Hepatitis, and Related Conditions Programs in the Office of Specialty Care Services and by the HAIG. There was no specific grant support for this study.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of interest
TRM would like to disclose that he receives funding for clinical trials from AbbVie, Merck, Gilead, and GenFit, not directly related to the current study. SR would like to disclose that her institution has received funding for research from Gilead, not directly related to the current study.
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Electronic supplementary material
Below is the link to the electronic supplementary material.
Rights and permissions
About this article
Cite this article
Dunn, S.H., Rogal, S.S., Maier, M.M. et al. Access to Comprehensive Services for Advanced Liver Disease in the Veterans Health Administration. Dig Dis Sci 64, 3471–3479 (2019). https://doi.org/10.1007/s10620-019-05785-2
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10620-019-05785-2