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Maintenance of Intestinal Epithelial Homeostasis by Zinc Transporters

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Abstract

Zinc is an essential micronutrient for normal organ function, and dysregulation of zinc metabolism has been implicated in a wide range of diseases. Emerging evidence has revealed that zinc transporters play diverse roles in cellular homeostasis and function by regulating zinc trafficking via organelles or the plasma membrane. In the gastrointestinal tract, zinc deficiency leads to diarrhea and dysfunction of intestinal epithelial cells. Studies also showed that zinc transporters are very important in intestinal epithelial homeostasis. In this review, we describe the physiological roles of zinc transporters in intestinal epithelial functions and relevance of zinc transporters in gastrointestinal diseases.

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Acknowledgments

Some studies described herein were supported by grants from the Japan Society for the Promotion of Science (17K09373 to WO and 17H04011 to TF) and Vehicle Racing Commemorative Foundation (TF).

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Authors and Affiliations

  1. Department of Molecular and Medical Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences for Research, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan

    Wakana Ohashi

  2. Molecular and Cellular Physiology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, 180 Nishihamabouji, Yamashiro, Tokushima, 770-8055, Japan

    Takafumi Hara, Teruhisa Takagishi & Toshiyuki Fukada

  3. Division of Biochemistry, Faculty of Pharmacy, Keio University, 1-5-30 Shibakoen, Minato-ku, Tokyo, 105-8512, Japan

    Koji Hase

  4. Division of Pathology, Department of Oral Diagnostic Sciences, School of dentistry, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8555, Japan

    Toshiyuki Fukada

  5. RIKEN Center for Integrative Medical Sciences, 1-7-22, Suehiro-cho, Tsurumi-ku, Yokohama City, Kanagawa, 230-0042, Japan

    Toshiyuki Fukada

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  1. Wakana Ohashi
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Ohashi, W., Hara, T., Takagishi, T. et al. Maintenance of Intestinal Epithelial Homeostasis by Zinc Transporters. Dig Dis Sci 64, 2404–2415 (2019). https://doi.org/10.1007/s10620-019-05561-2

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