Anterograde Endoscopic Ultrasound-Guided Pancreatic Duct Drainage: A Technical Review


The advancement of pancreatic endotherapy has increased the availability of minimally invasive endoscopic pancreatic ductal drainage techniques. In this regard, familiarity with endoscopic ultrasound-guided pancreatic duct drainage (EUS-PDD) is critical for treatment of obstructed pancreatic ductal systems, especially in nonsurgical candidates and in patients desiring a minimally invasive approach. Two distinct forms of EUS-PDD exist, viz. rendezvous-assisted endoscopic retrograde pancreatography (rendezvous-assisted ERP) and anterograde EUS-PDD. Anterograde EUS-PDD refers to transmural anterograde passage of a pancreatic drainage catheter or stent directly into the main pancreatic duct, through either the gastric or enteral wall. Rendezvous-assisted ERP should be attempted after failed conventional ERP, and anterograde EUS-PDD should be considered if rendezvous-assisted ERP fails or is not technically feasible. Common clinical scenarios that fulfil these conditions are chronic pancreatitis with high-grade main pancreatic duct obstruction, surgically altered anatomy with ductal/anastomotic obstruction, pancreas divisum, and disconnected pancreatic duct syndrome. The focus of this review article is anterograde EUS-PDD and its indications, technique, and outcomes. It also provides a summary of our own experience with this procedure, and a video demonstration of the technique.

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Correspondence to John Y. Nasr.

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Step-by-step video, with narration, of anterograde EUS-PDD. This video was made during the index procedure for case (patient) number 1, shown in Table 2 (MP4 131,466 kb)

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Krafft, M.R., Nasr, J.Y. Anterograde Endoscopic Ultrasound-Guided Pancreatic Duct Drainage: A Technical Review. Dig Dis Sci 64, 1770–1781 (2019).

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  • Anterograde endoscopic ultrasound-guided pancreatic duct drainage
  • Pancreaticogastrostomy
  • Endoscopic ultrasound
  • Chronic pancreatitis
  • Pancreaticojejunostomy
  • Disconnected pancreatic duct syndrome