Skip to main content

Gammadelta T Cells: Unconventional T Cells Involved in IBD Pathogenesis

This is a preview of subscription content, access via your institution.

References

  1. Giuffrida P, Corazza GR, Di Sabatino A. Old and new lymphocyte players in inflammatory bowel disease. Dig Dis Sci. 2018;63:277–288.

    Article  PubMed  CAS  Google Scholar 

  2. Goldberg R, Prescott N, Lord GM, MacDonald TT, Powell N. The unusual suspects–innate lymphoid cells as novel therapeutic targets in IBD. Nat Rev Gastroenterol Hepatol. 2015;12:271–283.

    Article  PubMed  CAS  Google Scholar 

  3. Treiner E. Mucosal-associated invariant T cells in inflammatory bowel diseases: bystanders, defenders, or offenders? Front Immunol. 2015;6:27.

    PubMed  PubMed Central  Google Scholar 

  4. Andreu-Ballester JC, Amigó-García V, Catalán-Serra I, et al. Deficit of gammadelta T lymphocytes in the peripheral blood of patients with Crohn’s disease. Dig Dis Sci. 2011;56:2613–2622.

    Article  PubMed  Google Scholar 

  5. Catalan Serra I, Bruland T, Sandvik A, et al. Gammadelta T cells deficiency in the peripheral blood of patients with Crohn’s disease: inverse correlation with clinical and endoscopical activity. Gastroenterology. 2017;5(Suppl1):S616.

    Article  Google Scholar 

  6. Mann ER, McCarthy NE, Peake ST, et al. Skin- and gut-homing molecules on human circulating γδT cells and their dysregulation in inflammatory bowel disease. Clin Exp Immunol. 2012;170:122–130.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  7. McCarthy NE, Hedin CR, Sanders TJ, et al. Azathioprine therapy selectively ablates human Vδ2+ T cells in Crohn’s disease. J Clin Invest. 2015;125(3215–25):41.

    Google Scholar 

  8. Kadivar M, Petersson J, Svensson L, Marsal J. CD8αβ+ γδT cells: a novel T cell subset with a potential role in inflammatory bowel disease. J Immunol. 2016;197:4584–4592.

    Article  PubMed  CAS  Google Scholar 

  9. Deusch K, Lüling F, Reich K, Classen M, Wagner H, Pfeffer K. A major fraction of human intraepithelial lymphocytes simultaneously expresses the gamma/delta T cell receptor, the CD8 accessory molecule and preferentially uses the V delta 1 gene segment. Eur J Immunol. 1991;21:1053–1059.

    Article  PubMed  CAS  Google Scholar 

  10. Chien YH, Meyer C, Bonneville M. γδT cells: first line of defense and beyond. Annu Rev Immunol. 2014;32:121–155.

    Article  PubMed  CAS  Google Scholar 

  11. Catalan-Serra I, Sandvik AK, Bruland T, Andreu-Ballester JC. Gammadelta T cells in Crohn’s disease: a new player in the disease pathogenesis? J Crohns Colitis. 2017. https://doi.org/10.1093/ecco-jcc/jjx039.

    PubMed  Article  Google Scholar 

  12. Inagaki-Ohara K, Chinen T, Matsuzaki G, et al. Mucosal T cells bearing TCR gammadelta play a protective role in intestinal inflammation. J Immunol. 2004;173:1390–1398.

    Article  PubMed  CAS  Google Scholar 

  13. Hoffmann JC, Pawlowski NN, Grollich K, Loddenkemper C, Zeitz M, Kühl AA. Gammadelta T lymphocytes: a new type of regulatory T cells suppressing murine 2,4,6-trinitrobenzene sulphonic acid [TNBS]-induced colitis. Int J Colorectal Dis. 2008;23:909–920.

    Article  PubMed  Google Scholar 

  14. Andreu-Ballester JC, Garcia-Ballesteros C, Amigo V, et al. Microsporidia and its relation to Crohn’s disease. A retrospective study. PLoS One. 2013;8:e62107.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  15. Dart RJ, Vantourout P, Laing A, et al. DOP075 Colonic gamma delta T-cells respond innately to NKG2D ligands and are grossly dysregulated in active inflammatory bowel disease. J Crohns Colitis. 2018;12(Suppl. 1):S081. https://doi.org/10.1093/ecco-jcc/jjx180.112.

    Article  Google Scholar 

  16. Li J, Ueno A, Iacucci M, et al. Crossover subsets of CD4(+) T lymphocytes in the intestinal lamina propria of patients with Crohn’s disease and ulcerative colitis. Dig Dis Sci. 2017;62:2357–2368.

    Article  PubMed  CAS  Google Scholar 

  17. Alfen JS, Larghi P, Facciotti F, et al. Intestinal IFN-γ-producing type 1 regulatory T cells coexpress CCR5 and programmed cell death protein 1 and downregulate IL-10 in the inflamed guts of patients with inflammatory bowel disease. J Allergy Clin Immunol. 2018 Jan 31. (Epub ahead of print).

  18. Paroni M, Magarotto A, Tartari S, et al. Uncontrolled IL-17 production by intraepithelial lymphocytes in a case of non-IPEX autoimmune enteropathy. Clin Transl Gastroenterol. 2016;7:e182.

    Article  PubMed  PubMed Central  Google Scholar 

  19. Backert I, Koralov SB, Wirtz S, et al. STAT3 activation in Th17 and Th22 cells controls IL-22-mediated epithelial host defense during infectious colitis. J Immunol. 2014;193:3779–3791.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Ignacio Catalan-Serra.

Ethics declarations

Conflict of interest

None.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Catalan-Serra, I., Andreu-Ballester, J.C., Bruland, T. et al. Gammadelta T Cells: Unconventional T Cells Involved in IBD Pathogenesis. Dig Dis Sci 63, 1977–1979 (2018). https://doi.org/10.1007/s10620-018-5059-7

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10620-018-5059-7