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Digestive Diseases and Sciences

, Volume 63, Issue 6, pp 1605–1612 | Cite as

Curative Criteria After Endoscopic Resection for Superficial Esophageal Squamous Cell Carcinomas

  • T. Mizumoto
  • T. Hiyama
  • S. Oka
  • N. Yorita
  • K. Kuroki
  • M. Kurihara
  • Y. Yoshifuku
  • Y. Sanomura
  • Y. Urabe
  • Y. Murakami
  • K. Arihiro
  • S. Tanaka
  • K. Chayama
Original Article
  • 93 Downloads

Abstract

Background

According to the Japanese Esophageal Society (JES) guidelines, risk factors for lymph node (LN) metastasis in the muscularis mucosa (MM)/submucosa to a depth of up to 200 μm (SM1) in cases of esophageal squamous cell carcinomas (ESCCs) include the presence of lymphatic invasion (ly), venous invasion (v), infiltration pattern (INF)c, and SM1. The long-term prognoses of these patients are unclear, and there are very few reports on the validation of the curative criteria for MM/SM1 ESCCs.

Aims

To examine the long-term prognoses of these patients and the risk factors for LN metastasis of MM/SM1 ESCCs after endoscopic resection (ER).

Methods

This study included patients with MM/SM1 ESCCs who underwent ER at Hiroshima University Hospital from December 1990 to November 2016. We evaluated the clinicopathological characteristics of 98 patients and overall survival, disease-specific survival, recurrence-free survival, and recurrence rates in the e-curative and non-e-curative groups.

Results

The mean observation period was 75 months. There was no significant difference in disease-specific survival rate between the e-curative and non-e-curative groups (100 vs. 98%). There was no significant difference in disease-specific survival rates between the groups (100 vs. 98%). In contrast, the LN recurrence-free survival rate in patients with INFa, ly(−), and v(−) was significantly higher than that in patients with INFb/c, ly(+), or v(+) (100 and 87%, P < 0.05).

Conclusion

Contrary to the JES guidelines, our findings suggest that new criteria (MM/SM1, INFa, negative vertical margin (VM0), ly[-], and v[-]) may be associated with curative ER without additional treatment.

Keywords

Esophageal cancers Endoscopic treatment Endoscopic resection Prognosis Metastasis 

Notes

Author’s contribution

TK and TH were involved in study conception and design; TK, NY, KK, MK, YY, YS, YU, YM, SO, and KA analyzed the data; ST and KC critically revised the manuscript for ensuring accuracy of content; and TK and TH wrote the manuscript.

Compliance with ethical standards

Conflict of interest

All the authors declare that they have no conflict of interests.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • T. Mizumoto
    • 1
  • T. Hiyama
    • 2
  • S. Oka
    • 1
  • N. Yorita
    • 1
  • K. Kuroki
    • 1
  • M. Kurihara
    • 1
  • Y. Yoshifuku
    • 1
  • Y. Sanomura
    • 3
  • Y. Urabe
    • 4
  • Y. Murakami
    • 5
  • K. Arihiro
    • 6
  • S. Tanaka
    • 3
  • K. Chayama
    • 1
  1. 1.Department of Gastroenterology and MetabolismHiroshima University HospitalHiroshimaJapan
  2. 2.Health Service CenterHiroshima UniversityHigashihiroshimaJapan
  3. 3.Department of EndoscopyHiroshima University HospitalHiroshimaJapan
  4. 4.Department of Regeneration and Medicine, Medical Center for Translational and Clinical ResearchHiroshima University HospitalHiroshimaJapan
  5. 5.Department of Radiation OncologyHiroshima University Graduate School of Biomedical SciencesHiroshimaJapan
  6. 6.Department of Anatomical PathologyHiroshima University HospitalHiroshimaJapan

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