Digestive Diseases and Sciences

, Volume 63, Issue 5, pp 1143–1147 | Cite as

Latent Hepatitis Virus Reactivation Due to Drug Reaction: DRESSed to Kill?

  • David Alexanian
  • Aleksandr Birg
  • Nicholas Volpicelli
  • Joseph Glass
  • Denis McCarthy
UNM Clinical Case Conferences


A 48-year old man was admitted to hospital with the new onset of a rash and abnormal liver function tests. The patient’s medical history included well-controlled diabetes mellitus type 2, gout, hyperlipidemia, stage 3 chronic kidney disease, and chronic low-back pain that had started 6 months prior to hospitalization; he had no known allergies. He had no relevant family or occupational history and lived with his wife. He denied smoking or illicit drug use and drank alcohol only in moderation.

He had been complaining of back pain in the lumbar region for several months; 3 months prior to the hospitalization had been evaluated in the emergency department, where magnetic resonance imaging (MRI) revealed changes consistent with osteomyelitis and a right psoas abscess at the level of the L4/L5 vertebrae. A CT-guided bone biopsy, cultured for bacteria, viruses, and fungi, failed to reveal any definite pathogen. He was therefore treated empirically, for culture-negative osteomyelitis,...


Rash HHV-6 Human herpesvirus 6 DRESS Drug reaction with eosinophilia and systemic symptoms Viral hepatitis Virus reactivation Latent virus Corticosteroid therapy Ganciclovir 


Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2018

Authors and Affiliations

  • David Alexanian
    • 1
  • Aleksandr Birg
    • 1
  • Nicholas Volpicelli
    • 1
  • Joseph Glass
    • 2
  • Denis McCarthy
    • 1
  1. 1.Division of Gastroenterology and HepatologyUniversity of New Mexico School of MedicineAlbuquerqueUSA
  2. 2.Department of PathologyUniversity of New Mexico School of MedicineAlbuquerqueUSA

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