Impact on Health-Related Quality of Life in Adults with Eosinophilic Gastritis and Gastroenteritis: A Qualitative Assessment
- 158 Downloads
Eosinophilic gastritis (EG) and eosinophilic gastroenteritis (EGE) are chronic immune-mediated conditions of the digestive tract, which affect the stomach only, or the stomach and small intestines, respectively. Though these disorders are uncommon, they are being increasingly recognized and diagnosed. While health-related quality of life (HRQOL) has been evaluated in other eosinophilic gastrointestinal diseases, this study is the first to describe HRQOL impacts unique to EG/EGE.
This study aims to qualitatively describe experiences of adults diagnosed with EG and EGE. We aim to identify impacts on HRQOL in this population in order to inform clinical care and assessment.
Seven patients diagnosed with EG or EGE participated in semi-structured interviews assessing common domains of HRQOL.
Four distinct themes emerged from qualitative analyses, which represent impacts to HRQOL: the psychological impact of the diagnosis, impact on social relationships, financial impact, and impact on the body. These generally improved over time and with effective treatment.
This study demonstrated that patients with EG/EGE experience impacts to HRQOL, some of which differ from HRQOL of other eosinophilic gastrointestinal diseases. These results support the development of a disease-specific measure, or adaptation of an existing measure, to assess HRQOL in EG/EGE.
KeywordsEosinophilic gastritis Eosinophilic gastroenteritis Health-related quality of life Patient-reported outcomes
Ms. Craven and Ms. Guadagnoli are supported by the T32DK101363 Training Grant in GI Physiology and Psychology.
Compliance with ethical statements
Conflict of interest
The authors have nothing to disclose and no competing interests.
- 7.Leffler DA, Acaster S, Gallop K, Dennis M, Kelly CP, Adelman DC. A novel patient-derived conceptual model of the impact of celiac disease in adults: implications for patient-reported outcome and health-related quality-of-life instrument development. Value Health. 2017;20:637–643.CrossRefPubMedGoogle Scholar
- 20.U.S. Department of Health and Human Services FDA Center for Drug Evaluation and Research, U.S. Department of Health and Human Services FDA Center for Biologics Evaluation and Research, U.S. Department of Health and Human Services FDA Center for Devices and Radiological Health. Guidance for Industry: Patient-Reported Outcome Measures: Use in Medical Product Development to Support Labeling Claims: Draft Guidance. Health Qual Life Outcomes. 2006; 4:79.Google Scholar
- 22.Ritchie J, Lewis J. Qualitative Research Practice: A Guide for Social Science Students and Researchers. Thousand Oaks, CA: Sage Publications; 2003.Google Scholar
- 25.Promotion OoDPaH. Health-related quality of life & well-being. 2017 [cited 2017].Google Scholar
- 30.Gerteis J, Izrael D, Deitz D, et al. Multiple Chronic Conditions Chartbook. Rockville, MD: Agency for Healthcare Research and Quality; 2014.Google Scholar
- 38.Braun V, Clarke V. Successful Qualitative Research: A Practical Guide for Beginners. London: Sage; 2013.Google Scholar