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Risk Factors for Hidradenitis Suppurativa in Patients with Inflammatory Bowel Disease

Digestive Diseases and Sciences volume 63, pages 755–760 (2018)Cite this article

Abstract

Background

Hidradenitis suppurativa (HS) is a chronic inflammatory skin disorder characterized by recurrent nodules, abscesses, and sinus tracts that can be debilitating and significantly impair quality of life. Small studies and case reports have suggested a possible association between HS and inflammatory bowel disease (IBD).

Aims

We performed a case–control study to further characterize IBD patients with HS in terms of smoking status, BMI, sites affected by HS, IBD type and features, and IBD medication history.

Methods

A total of 38 patients with HS and IBD were identified and matched on age, gender, and IBD type to 136 controls with IBD but not HS. Clinical characteristics of interest were obtained through extensive review of the electronic health record.

Results

Among patients with HS and IBD, the most common sites affected by HS were the inguinal, perianal, and axillary regions. Relative to patients with IBD alone, patients with HS and IBD were nearly six times more likely to be current smokers (p < 0.01) and nearly 11 times more likely to be obese (p < 0.01). Patients with HS and Crohn’s were significantly more likely to have ileocolonic and perianal disease than patients with CD only (OR 8.31, 95% CI 2.90–23.80 and OR 2.85, 95% CI 1.19–6.81, respectively; p < 0.01 for both).

Conclusions

Relative to patients with IBD who do not develop HS, patients with IBD and HS are more likely to be overweight or obese, to be former or current smokers, and to have ileocolonic and/or perianal disease.

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Acknowledgments

This project was supported in part by the National Institutes of Health through Grant Number UL1-TR-001857.

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Authors and Affiliations

  1. University of Pittsburgh School of Medicine, 3550 Terrace St, Pittsburgh, PA, 15213, USA

    Alexis J. Lukach

  2. Department of Medicine, University of Pittsburgh, 3471 Fifth Ave, 1216 Kaufmann Building, Pittsburgh, PA, 15213, USA

    Melissa I. Saul

  3. Department of Dermatology, University of Pittsburgh, 3601 Fifth Ave, 5th Floor, Pittsburgh, PA, 15213, USA

    Laura K. Ferris

  4. PRA Health Sciences, 4130 Parklake Ave, Suite 400, Raleigh, NC, 27612, USA

    Jason M. Swoger

Authors
  1. Alexis J. Lukach
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  2. Melissa I. Saul
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  3. Laura K. Ferris
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  4. Jason M. Swoger
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Corresponding author

Correspondence to Jason M. Swoger.

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The authors have no conflicts of interest to disclose.

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This manuscript represents original work and is not under consideration by any other journal. All authors approved the manuscript and this submission.

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Lukach, A.J., Saul, M.I., Ferris, L.K. et al. Risk Factors for Hidradenitis Suppurativa in Patients with Inflammatory Bowel Disease. Dig Dis Sci 63, 755–760 (2018). https://doi.org/10.1007/s10620-018-4919-5

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  • DOI: https://doi.org/10.1007/s10620-018-4919-5

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