Digestive Diseases and Sciences

, Volume 63, Issue 5, pp 1320–1326 | Cite as

Split-Dose Bowel Preparation Reduces the Need for Early Repeat Colonoscopy Without Improving Adenoma Detection Rate

  • Li Wang
  • Brandon S. Sprung
  • Arthur J. DeCross
  • Danielle Marino
Original Article


Background and Aims

Split-dose bowel preparation is associated with improved mucosal visualization and patient tolerance, becoming a standard of care. However, quality measures data associated with this preparation are limited. At our academic tertiary-care facility, we aim to study the effect of changing from single- to split-dose preparation on colonoscopy quality measures.


A retrospective cohort study with quality indicators was conducted using electronic medical record data. Cases were identified via ICD9 code V76.51, “Special screening for malignant neoplasms of colon.” Single-dose preparation data was collected from 9/1/13 to 8/31/14. Split-dose preparation was implemented 11/2014, and data were collected from 1/1/15 to 8/31/15.


A total of 1602 colonoscopies in the single-dose group and 1061 colonoscopies in the split-dose group were analyzed. The Boston Bowel Preparation Scale was significantly improved in the split-dose group 8.64 ± SD 1.25 versus 8.25 ± SD 1.61, p < 0.001. There was no significant difference in adenoma detection rate 40.7% (95% CI 37.8–43.7%) versus 40.5% (95% CI 38.1–42.9%), p = 0.92; however, the rate for recommending an early repeat examination due to an inadequate bowel preparation was significantly decreased to 3.9% (95% CI 2.7–5.0%) versus 8.9% (95% CI 1.52–2.97%), p < 0.001.


While split-dose preparation significantly improves overall bowel cleanliness, there is no significant adenoma detection rate improvement with high baseline rate, suggesting a threshold which may not improve with enhanced preparations. Split-dose preparation significantly reduces the frequency with which inadequate preparation prompts an early repeat examination, which has important clinical implications on performance, costs, and patient experience, providing further evidence supporting split-dose preparation use.


Adenoma detection rate Boston Bowel Preparation Scale Early repeat colonoscopy High baseline ADR 


Author’s contribution

Each author has participated substantially in the work and approves the manuscript.

Compliance with ethical standards

Conflict of interest

The authors have no conflicts of interest to disclose. The authors have not received any funding from or have any pecuniary interests in companies producing technology or projects related to this research.

Ethical standard

The project was reviewed by and approved by the Institutional Review Board at the University of Rochester Medical Center.

Grant support

No grants or other financial assistance was provided for this study.


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2017

Authors and Affiliations

  1. 1.Department of Medicine –Internal Medicine Residency ProgramUniversity of MassachusettsWorcesterUSA
  2. 2.Division of Gastroenterology and Hepatology, University of Rochester Medical CenterUniversity of RochesterRochesterUSA

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