Digestive Diseases and Sciences

, Volume 62, Issue 10, pp 2908–2914 | Cite as

Clinical Course of Partial Virologic Response with Prolonged Tenofovir Therapy in Nuclos(t)ides-Naïve Patients with Chronic Hepatitis B

  • In Du Jeong
  • Seok Won Jung
  • Bo Ryung Park
  • Byung Uk Lee
  • Jae Ho Park
  • Byung Gyu Kim
  • Sung-Jo Bang
  • Jung Woo Shin
  • Neung Hwa ParkEmail author
Original Article



The clinical course of chronic hepatitis B (CHB) patients with partial virologic response (PVR) during tenofovir disoproxil fumarate (TDF) therapy remains unclear.


We retrospectively investigated the long-term clinical outcomes of TDF treatment in nucleos(t)ides-naïve CHB patients, particularly in those with PVR.


A total of 391 patients treated with TDF therapy for more than 12 months were included. Virologic response (VR) was achieved in 341 patients (87.2%). PVR was evident in 127 (45.3%) of the 391 patients. Multivariate logistic regression analysis using selected baseline factors identified absolute HBV DNA levels at baseline (OR 0.496; 95% CI 1.369–1.969) and HBeAg positivity (OR 0.622; 95% CI 1.096–3.167) as factors significantly associated with PVR. During continuous prolonged TDF therapy, 127 (71.8%) of 177 patients with PVR achieved VR. The cumulative rates of VR in patients with PVR at 12, 24, and 36 months were 42.4, 79.7, and 90.2%, respectively. Serum HBV DNA level at week 24 was significantly associated with VR in patients with PVR.


The vast majority of CHB patients with PVR achieved VR through prolonged TDF therapy, although the time to achieve VR was delayed in those with PVR. This suggests that adjustment of TDF therapy in patients with PVR is unnecessary.


Tenofovir Partial virologic response Chronic hepatitis B 



Hepatitis B virus




Tenofovir disoproxil fumarate




Chronic hepatitis B


Partial virologic response


Hepatitis B e antigen


Virologic response


Virologic breakthrough


Confidence interval


Odds ratio


Receiver operating characteristic


Area under the ROC curve


Hepatitis B surface antigen



This work was supported by Priority Research Center Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science, and Technology (2010-0029621).

Compliance with ethical standards

Conflict of interest

The authors declared that they have no conflict of interest.


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© Springer Science+Business Media, LLC 2017

Authors and Affiliations

  1. 1.Department of Internal Medicine, Ulsan University HospitalUniversity of Ulsan College of MedicineUlsanRepublic of Korea
  2. 2.Biomedical Research Center, Ulsan University HospitalUniversity of Ulsan College of MedicineUlsanRepublic of Korea

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