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Hepatic Dysfunction in Renal Cell Carcinoma: Not What You Think?

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References

  1. Stauffer M. Nephrogenic hepatosplenomegaly. Gastroenterology. 1961;40:694.

    Google Scholar 

  2. Blay JY, Rossi JF, Wijdenes J, Menetrier-Caux C, et al. Role of interleukin-6 in the paraneoplastic inflammatory syndrome associated with renal-cell carcinoma. Int J Cancer. 1997;72:424–430.

    Article  CAS  PubMed  Google Scholar 

  3. Gold PJ, Fefer A, Thompson JA. Paraneoplastic manifestations of renal cell carcinoma. Semin Urol Oncol. 1996;14:216–222.

    CAS  PubMed  Google Scholar 

  4. Motzer RJ, Bander NH, Nanus DM. Renal-cell carcinoma. N Engl J Med. 1996;335:865–875.

    Article  CAS  PubMed  Google Scholar 

  5. Hinostroza-Yanahuaya J, Mon-Mon C, Ortega-Marcos O, Herrero-Berron JC, et al. Stauffer syndrome and prostate carcinoma; two cases in chronic haemodialysis patients. Nefrologia. 2013;33:749–750.

    PubMed  Google Scholar 

  6. Saintigny P, Spano JP, Tcherakian F, Pailler MC, et al. Non-metastatic intrahepatic cholestasis associated with bronchial adenocarcinoma. Ann Med Intern. 2003;154:171–175.

    Google Scholar 

  7. Sharara AI, Panella TJ, Fitz JG. Paraneoplastic hepatopathy associated with soft tissue sarcoma. Gastroenterology. 1992;103:330–332.

    Article  CAS  PubMed  Google Scholar 

  8. Moreno-Palacios J, Wingartz-Plata H, Pardo-Belasteguigoitia P, Moreno-Aranda J. Stauffer syndrome in transitional cell carcinoma of the bladder. Arch Esp Urol. 2011;64:911–913.

    PubMed  Google Scholar 

  9. Watterson J, Priest JR. Jaundice as a paraneoplastic phenomenon in a T-cell lymphoma. Gastroenterology. 1989;97:1319–1322.

    Article  CAS  PubMed  Google Scholar 

  10. Mendogni P, Rosso L, Tosi D, Palleschi A, et al. Autoimmune hepatitis: an uncommon presentation of thymoma. Tumori. 2016;102:40–42.

    Article  Google Scholar 

  11. Oguro T, Ishibashi K, Sugino T, Hashimoto K, et al. Humanised antihuman IL-6R antibody with interferon inhibits renal cell carcinoma cell growth in vitro and in vivo through suppressed SOCS3 expression. Eur J Cancer. 2013;49:1715–1724.

    Article  CAS  PubMed  Google Scholar 

  12. Su H, Lei C-T, Zhang C. Interleukin-6 signaling pathway and its role in kidney disease: an update. Front Immunol. 2017;8:405. doi:10.3389/fimmu.2017.00405.

    Article  PubMed  PubMed Central  Google Scholar 

  13. Aigner E, Strassburg CP, Strasser M, Pohla-Gubo G, et al. Transient autoimmune hepatitis induced by a thymoma. Am J Gastroenterol. 2009;104:1332–1334.

    Article  CAS  PubMed  Google Scholar 

  14. Chang S, Yu D, Sherwood E, Koslowski J, et al. Inhibitory effects of Suramin on a human renal cell carcinoma line, causing nephrogenic hepatic dysfunction. J Urol. 1992;47:1147–1150.

    Article  Google Scholar 

  15. Chuang YC, Lin AT, Chen KK, Chang YH, et al. Paraneoplastic elevation of serum alkaline phosphatase in renal cell carcinoma: incidence and implication on prognosis. J Urol. 1997;158:1684–1687.

    Article  CAS  PubMed  Google Scholar 

  16. Strickland RC, Schenker S. The nephrogenic hepatic dysfunction syndrome: a review. Am J Dig Dis. 1977;22:49–55.

    Article  CAS  PubMed  Google Scholar 

  17. Delpre G, Ilie B, Papo J, Streifler C, et al. Hypernephroma with nonmetastatic liver dysfunction (Stauffer’s syndrome) and hypercalcemia. Case report and review of the literature. Am J Gastroenterol. 1979;72:239–427.

    CAS  PubMed  Google Scholar 

  18. Puga M, Gonzalez-Ballina E, Rivas-Moral L. Stauffer’s syndrome: variant as an unusual case of painless jaundice. Clin Gastroenterol Hepatol. 2015;13:25–26.

    Article  Google Scholar 

  19. Jangouk P, Hashash JG. An unusual cause of painless jaundice. Renal cell carcinoma (Stauffer syndrome). Gastroenterology. 2014;146:913.

    Article  PubMed  Google Scholar 

  20. Akbulut S, Baysal A, Topal F. Paraneoplastic presentation of cholestatic jaundice in renal cell carcinoma. Turk J Gastroenterol. 2014;25:340–341.

    Article  PubMed  Google Scholar 

  21. Fernandez AB, De Avila AS. Prothrombin complex concentrate (Octaplex(R)) for postsurgical bleeding control in a Stauffer’s syndrome. Ann Hematol. 2012;91:1325–1326.

    Article  PubMed  Google Scholar 

  22. Woldie I, Manickam P, Choi M, Shi D, et al. An infrequent variant of Stauffer’s syndrome. Acta Gastroenterol Belg. 2012;75:379–380.

    CAS  PubMed  Google Scholar 

  23. Tomadoni A, García C, Márquez M, Ayala JC, et al. Stauffer’s syndrome with jaundice, a paraneoplastic manifestation of renal cell carcinoma: a case report. Arch Esp Urol. 2010;63:154–156.

    Article  PubMed  Google Scholar 

  24. Girotra M, Abraham RR, Pahwa M, Arora M. Is Stauffer’s syndrome an early indicator of RCC recurrence? ANZ J Surg. 2010;80:949–950.

    Article  PubMed  Google Scholar 

  25. Kranidiotis GP, Voidonikola PT, Dimopoulos MK, Anastasiou-Nana M. Stauffer’s syndrome as a prominent manifestation of renal cancer: a case report. Cases J. 2009;2:49–52.

    Article  PubMed  PubMed Central  Google Scholar 

  26. Yong TL, Birks SE, Rudinski C. Stauffer’s syndrome. ANZ J Surg. 2008;78:1138–1139.

    PubMed  Google Scholar 

  27. Morla D, Alazemi S, Lichtstein D. Stauffer’s syndrome variant with cholestatic jaundice: a case report. J Gen Intern Med. 2006;21:11–13.

    Article  Google Scholar 

  28. Giannakos G, Papanicolaou X, Trafalis D, Michaelidis I, et al. Stauffer’s syndrome variant associated with renal cell carcinoma. Int J Urol. 2005;12:757–759.

    Article  PubMed  Google Scholar 

  29. Dourakis SP, Sinani C, Deutsch M, Dimitriadou E, et al. Cholestatic jaundice as a paraneoplastic manifestation of renal cell carcinoma. Eur J Gastroenterol Hepatol. 1997;9:311–314.

    Article  CAS  PubMed  Google Scholar 

  30. Fang JW, Lau JY, Wu PC, Lai CL. Fulminant hepatic failure in nonmetastatic renal cell carcinoma. Dig Dis Sci. 1992;37:474–477.

    Article  CAS  PubMed  Google Scholar 

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Gremida, A., Al-Taee, A., Alcorn, J. et al. Hepatic Dysfunction in Renal Cell Carcinoma: Not What You Think?. Dig Dis Sci 62, 2298–2302 (2017). https://doi.org/10.1007/s10620-017-4706-8

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