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Evolution of Clinical Behavior in Crohn’s Disease: Factors Associated with Complicated Disease and Surgery

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Abstract

Background

The phenotypic expression of Crohn’s disease may vary over time. Establishment of Crohn’s disease phenotypes is important for definition of patient care strategies.

Aims

The aim of the study was to evaluate the long-term evolution of patients based on disease phenotypes and the main factors associated with this evolution.

Methods

Data from 179 patients were collected from a unicentric prospective database. Montreal classification was employed. Kaplan–Meier method was used to estimate the cumulative probability of complication development and surgery. Poisson regression for multivariate analysis was applied. The Local Institutional Review Board approved the research.

Results

Female: 54.2%. Mean age at diagnosis: 32.7 (±13.7) years. Behavior at presentation: inflammatory 62.0%, stricturing 24.6%, penetrating 13.4%; perianal disease: 31.8%; median follow-up time: 65.2 months (IQR 31.0–108.8). Behavior at follow-up period end: inflammatory 43.6%, stricturing 38.0%, penetrating 18.4%; perianal disease: 46.4%. Cumulative probability of being complication free in 5, 10, and 20 years: 86.3, 66.4, and 52.2%, respectively. Cumulative probability of being surgery free in 5, 10, and 20 years: 87.3, 79.2, and 64.1%, respectively. L1 and L4 locations, use of immunosuppressive therapy, smoking, number of hospitalization/patient-year, abdominal surgery, age at diagnosis <40 years, and biological therapy were the factors associated with changes in phenotype or development of complications and perianal disease.

Conclusion

Clinical behavior altered in about one-third of patients. The most frequent complication was a change to stricturing pattern. Disease location, current smoker, immunosuppressive therapy use, hospitalization, and abdominal surgery were factors associated with an unfavorable clinical evolution.

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Authors and Affiliations

  1. Division of Gastroenterology, Hospital de Clínicas de Porto Alegre, Medical School, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2350, Porto Alegre, RS, 90035-903, Brazil

    Kátia Simone Cezário de Barros, Cristina Flores, Luciana Harlacher & Carlos Fernando Magalhães Francesconi

  2. Rodovia BR 424, Km 94, 134, Condomínio Mont Serrat, Quadra A, casa 03, Garanhuns, PE, 55292-125, Brazil

    Kátia Simone Cezário de Barros

Authors
  1. Kátia Simone Cezário de Barros
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  2. Cristina Flores
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  3. Luciana Harlacher
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  4. Carlos Fernando Magalhães Francesconi
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Correspondence to Kátia Simone Cezário de Barros.

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de Barros, K.S.C., Flores, C., Harlacher, L. et al. Evolution of Clinical Behavior in Crohn’s Disease: Factors Associated with Complicated Disease and Surgery. Dig Dis Sci 62, 2481–2488 (2017). https://doi.org/10.1007/s10620-017-4685-9

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  • DOI: https://doi.org/10.1007/s10620-017-4685-9

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