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Increased Proliferative Activity Accompanies the Local Inflammatory Response of Gastric Mucosa After Intragastric Balloon Insertion

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Abstract

Background and Aim

The use of BioEnterics intragastric balloon (BIB) is progressively increasing, owing to the fact that morbid obesity becomes a global epidemic together with risks of bariatric surgery. Yet, the possible local BIB effect on gastric mucosa is not clearly elucidated. The aim of the current study was to assess the histological changes occurring in the gastric mucosa post-BIB insertion.

Methods

Gastric mucosa biopsy was obtained from 87 cases of morbid obesity both pre-BIB and 6 months post-BIB insertion to compare the local changes by histological and immunohistochemical analysis.

Results

An inflammatory reaction was detected in the post-BIB mucosa which displayed a positive CD20, CD3 (p < 0.05), and the proliferation index (Ki67) increased significantly compared with that of the pre-BIB cases. The Ki67 index showed a significant positive correlation with CD20 and CD3 immunoexpression in the post-BIB gastric mucosae.

Conclusion

Our results demonstrated a possible increase in the gastric proliferative activity after BIB insertion accompanied with a remarkable local inflammatory reaction. Although these findings may be reactive and transient, endoscopic follow-up is recommended for early detection of further pathological changes.

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Authors and Affiliations

  1. Gastroenterology Surgical Center, Faculty of Medicine, Mansoura University, Mansoura, Egypt

    Ehab Atef

  2. Department of Pathology, Faculty of Medicine, Mansoura University, Mansoura, Egypt

    Khaled Refaat Zalata

  3. Department of Histology and Cell Biology, Faculty of Medicine, Mansoura University, Mansoura, Egypt

    Hoda Atef & Ahmed A. M. Abdel-Hamid

Authors
  1. Ehab Atef
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  2. Khaled Refaat Zalata
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  3. Hoda Atef
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  4. Ahmed A. M. Abdel-Hamid
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Correspondence to Ahmed A. M. Abdel-Hamid.

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Atef, E., Zalata, K.R., Atef, H. et al. Increased Proliferative Activity Accompanies the Local Inflammatory Response of Gastric Mucosa After Intragastric Balloon Insertion. Dig Dis Sci 61, 3498–3505 (2016). https://doi.org/10.1007/s10620-016-4344-6

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  • DOI: https://doi.org/10.1007/s10620-016-4344-6

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