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Age and Prevalence of Esophageal Reflux Disease in Japanese Patients with Type 2 Diabetes Mellitus: The Dogo Study

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Abstract

Background

Only limited epidemiological evidence exists regarding the relationship between age and gastroesophageal reflux disease (GERD) among Japanese patients with type 2 diabetes mellitus.

Aim

The purpose of the present study is to investigate this issue among Japanese patients with type 2 diabetes mellitus.

Methods

A multicenter cross-sectional study was conducted in 847 Japanese patients with type 2 diabetes mellitus. Subjects were divided into quartiles according to age: (1) 19 ≤ age < 56, (2) 56 ≤ age < 64, (3) 64 ≤ age < 71, and (4) 71 ≤ age < 89. GERD was defined as present when a subject had a Carlsson–Dent self-administered questionnaire (QUEST) score ≥4.

Results

The prevalence of GERD was 31.5 %. Younger age was independently associated with a higher prevalence of GERD: the adjusted odds ratios (95 % confidence intervals) for GERD in relation to age < 56, 56 ≤ age < 64, 64 ≤ age < 71, and ≥71 were 3.73 (2.16–6.53), 1.98 (1.21–3.27), 1.66 (1.05–2.68), and 1.00 (reference), respectively (P for trend = 0.001). Among 201 patients with PPI or histamine H2-receptor antagonist (H2RA), less than 56 years of age was independently positively associated with GERD: the adjusted OR was 5.68 (95 % CI 1.55–22.18) (P for trend = 0.02).

Conclusions

Younger age may be independently positively associated with GERD among Japanese type 2 diabetes mellitus patients, regardless of the use of PPI or H2RA.

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Acknowledgments

This study was supported by JSPS KAKENHI Grants (21790583 and 23790697). We would like to thank Teruhisa Ueda from Ehime Prefectural Central Hospital, Masamoto Torisu from Saiseikai Saijo Hospital, Hisaka Minami from Ehime Niihama Hospital, Morikazu Onji from Saiseikai Imabari Hospital, Koutastsu Maruyama and Takeshi Tanigawa from Juntendo University, Eriko Kawamoto from University of The Ryukyus, Tomo Kogama and Keiko Kikuchi from Ehime University, and Eri Furukawa from Furukawa Clinic.

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    Authors and Affiliations

    1. Endoscopy Center, Ehime University Hospital, Shitsukawa, Toon, Ehime, 791-0295, Japan

      Yoshio Ikeda, Yasunori Yamamoto & Hiroki Utsunomiya

    2. Department of Epidemiology and Preventive Medicine, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime, 791-0295, Japan

      Shinya Furukawa, Hidenori Senba, Keiko Tanaka & Yoshihiro Miyake

    3. Epidemiology and Medical Statistics Unit, Translational Research Center, Ehime University Hospital, Shitsukawa, Toon, Ehime, 791-0295, Japan

      Shinya Furukawa, Keiko Tanaka & Yoshihiro Miyake

    4. Department of Internal Medicine, Yawatahama General City Hospital, Yawatahama, Ehime, 796-8502, Japan

      Takenori Sakai

    5. Department of Internal Medicine, Matsuyama Shimin Hospital, Otemachi, Matsuyama, Ehime, 790-0067, Japan

      Tetsuji Niiya

    6. Department of Internal Medicine, Saiseikai Matsuyama Hospital, Yamanishi 880-2, Matsuyama, Ehime, 791-8026, Japan

      Hiroaki Miyaoka

    7. Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime, 791-0295, Japan

      Teruki Miyake, Hidenori Senba, Eiji Arimitsu & Yoichi Hiasa

    8. Department of Lifestyle-related Medicine and Endocrinology, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime, 791-0295, Japan

      Shin Yamamoto & Bunzo Matsuura

    9. Department of Inflammatory Bowel Diseases and Therapeutics, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime, 791-0295, Japan

      Sen Yagi & Eiji Takeshita

    Authors
    1. Yoshio Ikeda
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    2. Shinya Furukawa
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    Corresponding author

    Correspondence to Shinya Furukawa.

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    Yoshio Ikeda and Shinya Furukawa have contributed equally to this work and share first authorship.

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    Ikeda, Y., Furukawa, S., Sakai, T. et al. Age and Prevalence of Esophageal Reflux Disease in Japanese Patients with Type 2 Diabetes Mellitus: The Dogo Study. Dig Dis Sci 61, 3530–3536 (2016). https://doi.org/10.1007/s10620-016-4311-2

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    • DOI: https://doi.org/10.1007/s10620-016-4311-2

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