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Risk of Colorectal Neoplasia According to Fatty Liver Severity and Presence of Gall Bladder Polyps

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Abstract

Background

Fatty liver is the hepatic manifestation of metabolic syndrome (MetS) and is a known risk factor for colorectal neoplasia (CRN). Gallbladder (GB) polyps share many common risk factors with CRN. However, studies evaluating CRN risk according to fatty liver severity and the presence of GB polyps are rare.

Aim

To investigate CRN risk according to the fatty liver severity and the presence of GB polyps.

Methods

A retrospective cross-sectional study was performed on 44,220 participants undergoing colonoscopy and abdominal ultrasonography (US) as part of a health-screening program.

Results

Of the participants, fatty liver was diagnosed as mild in 27.7 %, moderate in 5.1 %, and severe in 0.4 % and 13.4 % were diagnosed with GB polyps. Mean age of participants was 42.7 years. In adjusted models, risk of overall CRN and non-advanced CRN increased with worsening fatty liver severity (P for trend = 0.007 and 0.020, respectively). Adjusted odd ratios for overall CRN and non-advanced CRN comparing participants with mild, moderate, and severe fatty liver to participants without fatty liver were 1.13 and 1.12 for mild, 1.12 and 1.10 for moderate, and 1.56 and 1.65 for severe. The presence of GB polyps did not correlate with CRN risk after adjusting for confounders.

Conclusions

CRN risk increased with worsening fatty liver severity. However the association between GB polyp and CRN was not significant in the presence of other variables. Considering that many people undergo noninvasive abdominal US as a health screen, our study will contribute to colonoscopy screening strategies in people undergoing abdominal US.

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Authors and Affiliations

  1. Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University, School of Medicine, 108, Pyung-Dong, Jongro-Ku, Seoul, 110-746, Korea

    Taeyoung Lee, Dong Il Park, Kyuyong Choi & Yoon Suk Jung

  2. Center for Cohort Studies, Total Healthcare Center, Kangbuk Samsung Hospital, Sungkyunkwan University, School of Medicine, Seoul, Korea

    Kyung Eun Yun, Yoosoo Chang & Seungho Ryu

  3. Department of Occupational and Environmental Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University, School of Medicine, Seoul, Korea

    Yoosoo Chang & Seungho Ryu

Authors
  1. Taeyoung Lee
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  2. Kyung Eun Yun
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  3. Yoosoo Chang
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  4. Seungho Ryu
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  5. Dong Il Park
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  7. Yoon Suk Jung
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Correspondence to Yoon Suk Jung.

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Lee, T., Yun, K.E., Chang, Y. et al. Risk of Colorectal Neoplasia According to Fatty Liver Severity and Presence of Gall Bladder Polyps. Dig Dis Sci 61, 317–324 (2016). https://doi.org/10.1007/s10620-015-3873-8

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  • DOI: https://doi.org/10.1007/s10620-015-3873-8

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