Digestive Diseases and Sciences

, Volume 60, Issue 10, pp 3085–3091 | Cite as

Vitamin D Deficiency Associated with Disease Activity in Patients with Inflammatory Bowel Diseases

  • Mehdi Torki
  • Ali GholamrezaeiEmail author
  • Leila Mirbagher
  • Manijeh Danesh
  • Sara Kheiri
  • Mohammad Hassan Emami
Original Article



Evidence exists on the association between vitamin D deficiency and inflammatory bowel diseases (IBD).


To investigate whether vitamin D level is associated with disease activity and quality of life in IBD patients.


This cross-sectional study was conducted on known adult IBD patients referred to an outpatient clinic of gastroenterology in Isfahan city, Iran. Disease activity was evaluated using the Simplified Crohn’s Disease Activity Index and Simple Clinical Colitis Activity Index. Quality of life was assessed with the Short-Inflammatory Bowel Disease Questionnaire. Serum 25[OH]D was measured using the radioimmunoassay method. Vitamin D deficiency and insufficiency were defined as concentration of <50 and 50–75 nmol/L, respectively.


Studied subjects were 85 ulcerative colitis and 48 Crohn’s disease patients (54.1 % females) with mean age of 42.0 ± 14.0 years. Vitamin D deficiency and insufficiency were present in 52 (39.0 %) and 24 (18.0 %) patients, respectively. Thirty patients (22.5 %) had active disease who, compared with patients in remission, had more frequent low vitamin D levels (80 vs. 50.4 %, P = 0.005). Quality of life was not different between patients with low and those with normal vitamin D levels (P = 0.693). In the logistic regression model, low vitamin D was independently associated with active disease status, OR (95 % CI) = 5.959 (1.695–20.952).


We found an association between vitamin D deficiency/insufficiency and disease activity in IBD patients. Prospective cohorts and clinical trials are required to clarify the role of vitamin D deficiency and its treatment in clinical course of IBD.


Vitamin D 25-Hydroxyvitamin D Inflammatory bowel diseases Ulcerative colitis Crohn’s disease Quality of life 



This study was supported by the Isfahan University of Medical Sciences. The sponsor had no role in the study design, the collection, analysis and interpretation of data, writing of the manuscript, or the decision to submit the manuscript for publication. Author’s contributions were as follows: AGh and MHE participated in study conception and design. MT prepared the grant proposal. All authors participated in data collection and primary analysis. AGh performed statistical analysis. MT, AGh, and MHE participated in data analysis interpretation. MT, AGh, and LM prepared the manuscript draft. All authors studied, revised, and approved the final version of manuscript.

Conflicts of interest

There is no conflict of interest.


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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Mehdi Torki
    • 1
    • 2
  • Ali Gholamrezaei
    • 2
    • 3
    Email author
  • Leila Mirbagher
    • 3
  • Manijeh Danesh
    • 3
  • Sara Kheiri
    • 3
  • Mohammad Hassan Emami
    • 1
    • 2
  1. 1.Department of Internal MedicineIsfahan University of Medical SciencesIsfahanIran
  2. 2.Poursina Hakim Research InstituteIsfahanIran
  3. 3.Medical Students’ Research CenterIsfahan University of Medical SciencesIsfahanIran

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