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Preoperative Clostridium difficile Infection Is Not Associated with an Increased Risk for the Infection in Ileal Pouch Patients

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Abstract

Background

Clostridium difficile infection (CDI) might contribute to a refractory course of pouchitis. However, the association between preoperative CDI and postoperative CDI in ileal pouch patients has not been investigated.

Aim

Our study aimed to evaluate whether preoperative CDI had an impact on the occurrence of postoperative CDI in pouch patients.

Methods

Consecutive eligible ileal pouch patients from February 2005 to December 2012 were identified from the Pouchitis Registry at the Cleveland Clinic. Patients in the registry with known status of CDI of the pouch were surveyed with a structured questionnaire regarding preoperative C. difficile test and its treatment. Medical records were also reviewed. Demographics and clinical characteristics and outcomes were evaluated with univariable and multivariable analyses.

Results

A total of 102 patients with preoperative C. difficile test were identified for this study and 21 patients (20.6 %) tested positive for C. difficile test after colectomy. In logistic regression analysis, male patients were 7.85 (P = 0.003) times more likely to have CDI than women. In addition, preoperative significant comorbidities (P = 0.037) and preoperative use antibiotics for other indications (P = 0.005) were found to be associated with postoperative CDI of the pouch. However, there was no evidence to suggest that the preoperative CDI was associated with the occurrence of postoperative CDI (P = 0.769).

Conclusions

Postoperative CDI occurred frequently in male patients with IPAA. In addition, preoperative comorbidities and antibiotic use were found to be risk factors for CDI of the pouch. However, preoperative CDI did not appear to be associated with an increased risk for postoperative CDI in pouch patients.

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Acknowledgments

The project was supported by the Ed and Joey Story Chair (to B.S.).

Conflict of interest

None.

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Authors and Affiliations

  1. Department of Gastroenterology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200092, China

    Chao Sun

  2. Department of Colorectal Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200092, China

    Peng Du

  3. Departments of Gastroenterology/Hepatology and Colorectal Surgery, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH, 44195, USA

    Xian-rui Wu, Elaine Queener & Bo Shen

  4. Department of Gastroenterology, The Cleveland Clinic Foundation, Cleveland, OH, 44195, USA

    Chao Sun

  5. Department of Colorectal Surgery, The Cleveland Clinic Foundation, Cleveland, OH, 44195, USA

    Peng Du

Authors
  1. Chao Sun
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  2. Peng Du
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  3. Xian-rui Wu
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  4. Elaine Queener
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  5. Bo Shen
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Correspondence to Bo Shen.

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Sun, C., Du, P., Wu, Xr. et al. Preoperative Clostridium difficile Infection Is Not Associated with an Increased Risk for the Infection in Ileal Pouch Patients. Dig Dis Sci 59, 1262–1268 (2014). https://doi.org/10.1007/s10620-014-3047-0

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  • DOI: https://doi.org/10.1007/s10620-014-3047-0

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