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High Serum Vaspin Concentrations in Patients with Ulcerative Colitis

Digestive Diseases and Sciences volume 59, pages 315–321 (2014)Cite this article

Abstract

Background

Adipocytokines are associated with energy homeostasis and mediate various immune responses and inflammatory processes. Vaspin is a novel adipocytokine that is thought to exhibit anti-inflammatory effects.

Aim

We aimed to evaluate serum vaspin levels in inflammatory bowel disease (IBD) and determine its possible associations with the course and to clarify its intestinal localization.

Methods

Serum samples were obtained from patients with Crohn’s disease (CD; n = 30) and ulcerative colitis (UC; n = 33) and from healthy volunteers (controls; n = 26). Enzyme-linked immunosorbent assays were performed for all patients. Vaspin immunohistochemical staining was performed for intestines affected with IBD.

Results

Serum vaspin concentrations were significantly higher in patients with UC than in patients with CD and controls (422.9 ± 361.9 vs. 163.4 ± 116.2 vs. 147.5 ± 89.4 pg/mL, respectively; P < 0.01). There was no difference in the serum vaspin concentrations between the patients with CD and controls. There was also no difference in the serum vaspin concentrations between the patients with active IBD and those with inactive IBD. However, the serum vaspin concentrations of most patients with UC increased after remission induction. Vaspin was expressed in the adipocytes of the mesenteric adipose tissues but not in the epithelial or inflammatory cells of large intestines of the patients with IBD.

Conclusions

Serum vaspin concentrations are elevated in patients with UC and increase further after remission induction, suggesting that vaspin may aid the auxiliary diagnosis of UC and may be useful for assessing disease activity in patients.

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Affiliations

  1. Department of Gastroenterology and Hepatology, Graduate School of Biomedical Sciences, Nagasaki University, 1-7-1, Sakamoto, Nagasaki, 852-8501, Japan

    Tomohito Morisaki, Fuminao Takeshima, Hiroko Fukuda, Kayoko Matsushima, Yuko Akazawa, Naoyuki Yamaguchi, Ken Ohnita, Hajime Isomoto & Kazuhiko Nakao

  2. Division of Surgical Oncology, Department of Translational Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan

    Hiroaki Takeshita & Terumitsu Sawai

  3. Department of Surgery, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan

    Fumihiko Fujita

Authors
  1. Tomohito Morisaki
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  2. Fuminao Takeshima
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  3. Hiroko Fukuda
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  4. Kayoko Matsushima
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  5. Yuko Akazawa
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  6. Naoyuki Yamaguchi
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  7. Ken Ohnita
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  8. Hajime Isomoto
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  9. Hiroaki Takeshita
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  10. Terumitsu Sawai
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  11. Fumihiko Fujita
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  12. Kazuhiko Nakao
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Corresponding author

Correspondence to Fuminao Takeshima.

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Morisaki, T., Takeshima, F., Fukuda, H. et al. High Serum Vaspin Concentrations in Patients with Ulcerative Colitis. Dig Dis Sci 59, 315–321 (2014). https://doi.org/10.1007/s10620-013-2905-5

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  • DOI: https://doi.org/10.1007/s10620-013-2905-5

Keywords

  • Adipocytokine
  • Vaspin
  • Inflammatory bowel disease
  • Crohn’s disease
  • Ulcerative colitis