Abstract
Background
Endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) is an established procedure for the pathological diagnosis of gastrointestinal submucosal tumors (SMTs). Although bleeding and perforation are potentially severe complications of EUS-FNA, the incidences and severities of these complications have not yet been fully evaluated because of their relative rarity.
Aim
The purpose of this study was to evaluate the incidences and mortality of severe bleeding and perforation in patients who underwent EUS-FNA for SMTs.
Methods
The records of 1,135 consecutive patients who underwent EUS-FNA for SMTs at 219 hospitals, with low- to high-volume, were reviewed using a Japanese nationwide administrative database.
Results
Of the targeted lesions 73.5 % were located in the stomach, 13.4 % in the esophagus, 8.2 % in the duodenum, and 4.9 % at other sites. Five patients (0.44 %) experienced severe bleeding requiring red blood cell transfusion or endoscopic treatment, with none experiencing perforation. Only one patient (0.09 %) died in-hospital within 30 days of EUS-FNA (0.09 %), with death not associated with bleeding or perforation.
Conclusions
EUS-FNA is safe in evaluating SMTs, with low risks of bleeding and perforation.
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Acknowledgments
This study was funded by a Grant-in-Aid for Research on Policy Planning and Evaluation from the Ministry of Health, Labour and Welfare, Japan (Grant No. H22-Policy-031), by a Grant-in-Aid for Scientific Research B from the Ministry of Education, Culture, Sports, Science and Technology (Grant No. 22390131), and by the Funding Program for World-Leading Innovative R&D on Science and Technology (FIRST program) from the Council for Science and Technology Policy, Japan (Grant No. 0301002001001).
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Hamada, T., Yasunaga, H., Nakai, Y. et al. Rarity of Severe Bleeding and Perforation in Endoscopic Ultrasound-Guided Fine Needle Aspiration for Submucosal Tumors. Dig Dis Sci 58, 2634–2638 (2013). https://doi.org/10.1007/s10620-013-2717-7
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DOI: https://doi.org/10.1007/s10620-013-2717-7