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Small Intestinal Bacterial Overgrowth and Orocecal Transit Time in Patients of Inflammatory Bowel Disease

Digestive Diseases and Sciences volume 58, pages 2594–2598 (2013)Cite this article

Abstract

Background

Inflammatory bowel disease (IBD) consists of Ulcerative colitis (UC) and Crohn’s disease (CD). These two conditions share many common features—diarrhea, bloody stools, weight loss, abdominal pain, fever and fatigue. Small intestinal bacterial overgrowth (SIBO) is frequent in patients with CD but it has not been studied in UC Indian patients.

Aim

The study was planned to measure orocecal transit time (OCTT) and SIBO in UC and CD patients.

Methods

One hundred thirty-seven patients of IBD (95 UC and 42 CD) and 115 healthy controls were enrolled. OCTT and SIBO were measured by lactulose and glucose hydrogen breath test respectively. Concentration of hydrogen and methane were measured by SC microlyser from Quintron, USA.

Results

Mean ± standard deviation (SD) of OCTT in patients of IBD was significantly higher as compared to controls. Furthermore, OCTT was significantly higher in CD patients as compared to UC patients. It was also observed that occurrence of SIBO was significantly higher in IBD patients as compared to controls. The occurrence of SIBO in CD (45.2 %) was significantly higher as compared to patients in UC (17.8 %) group. Percentage of methane positive IBD patients (2.9 %) was significantly lower as compared to methane positive controls (24.4 %).

Conclusion

OCTT was significantly delayed in IBD patients as compared to controls and in CD patients as compared to UC patients. OCTT was significantly higher in SIBO positive IBD patients as compared to SIBO negative patients. Thus, we can suggest that delayed OCTT would have been the cause of increased SIBO in these patients.

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Acknowledgments

The authors would like to acknowledge the financial support given by the Indian Council of Medical Research (ICMR), New Delhi, no 5/4/3-2/07/NCD II.

Conflict of interest

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Affiliations

  1. Department of Super Specialty Gastroenterology, Post Graduate Institute of Medical Education and Research, Sector 12, Chandigarh, 160012, India

    S. V. Rana, S. Sharma, A. Malik, J. Kaur, K. K. Prasad, S. K. Sinha & K. Singh

  2. House No. 137, Sector 15 A, Chandigarh, 160012, India

    S. V. Rana

Authors
  1. S. V. Rana
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  2. S. Sharma
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  3. A. Malik
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  4. J. Kaur
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  5. K. K. Prasad
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  6. S. K. Sinha
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  7. K. Singh
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Correspondence to S. V. Rana.

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Rana, S.V., Sharma, S., Malik, A. et al. Small Intestinal Bacterial Overgrowth and Orocecal Transit Time in Patients of Inflammatory Bowel Disease. Dig Dis Sci 58, 2594–2598 (2013). https://doi.org/10.1007/s10620-013-2694-x

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  • DOI: https://doi.org/10.1007/s10620-013-2694-x

Keywords

  • Small intestinal bacterial overgrowth
  • Orocecal transit time
  • Ulcerative colitis
  • Crohn’s disease