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Predictive Risk Factors of Cardiorespiratory Abnormality for Upper Gastrointestinal Endoscopy in Tibet

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Abstract

Background

To explore the predictive factors of cardiorespiratory abnormality in nonsedated patients at high altitude (HA) during upper gastrointestinal endoscopy (UGIE).

Methods

The pulse and saturated oxygen (SaO2) levels of 993 patients undergoing nonsedated UGIE in Tibet were monitored. Bivariate correlation and logistic regression were used to identify predictive risk factors for hypoxemia.

Results

The basal and minimum SaO2 levels during UGIE of the Tibetan group were significantly higher than those of the non-Tibetan group. The minimum SaO2 and maximum pulse in the HA transient residents groups were significantly higher than those in the HA usual residents groups. The incidences of hypoxemia and severe hypoxemia in the Tibetan groups were significantly lower than those of the non-Tibetan groups. Bivariate correlation and logistic regression showed that race, age (≥40 years), residence time in HA (<10 years), and basal SaO2 (<89 %) were sufficiently effective to predict hypoxemia. High-risk hypoxemic patients whose residence time in HA was <2 years were more prone to severe hypoxemia. The combination of the four variables showed superior performance in hypoxemia prognosis (AUC-ROC, 0.941; sensitivity, 83.7 %; specificity, 92.5 %) and severe hypoxemia prognosis (AUC-ROC, 0.968; sensitivity, 90.3 %; specificity, 98.0 %).

Conclusions

Race, age, residence time in HA, and basal SaO2 of patients in HA were predictive variables for hypoxemia during UGIE. Non-Tibetan patients with age ≥40 years, residence time in HA <10 years, and basal SaO2 <89 % were prone to hypoxemia. Among those groups, patients whose residence time was <2 years were at higher risk for severe hypoxemia.

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Acknowledgment

We thank Medjaden Bioscience Limited for assisting in the preparation of this manuscript.

Conflict of interest

None.

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Authors and Affiliations

  1. Department of Gastroenterology, Changhai Hospital, The Second Military Medical University, 168 Changhai Road, Shanghai, 200433, China

    Feng Liu & Zhao Shen Li

  2. Department of Gastroenterology, Fuzhou Genaral Hospital of Nianjing Military Command, Fuzhou, Fujian, China

    Jian-qiang Liu

  3. Department of Thoracic Surgery, General Hospital of Tibet Military Command, Lhasa, Tibet, China

    Su-zhi Li

  4. Department of Gastroenterology, General Hospital of Tibet Military Command, Lhasa, Tibet, China

    You-wei Chen & De-qing Yangzong

Authors
  1. Feng Liu
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  2. Jian-qiang Liu
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  3. Su-zhi Li
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  4. You-wei Chen
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  5. De-qing Yangzong
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  6. Zhao Shen Li
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Corresponding author

Correspondence to Zhao Shen Li.

Additional information

Feng Liu, Jian-qiang Liu contributed equally to this study.

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Liu, F., Liu, Jq., Li, Sz. et al. Predictive Risk Factors of Cardiorespiratory Abnormality for Upper Gastrointestinal Endoscopy in Tibet. Dig Dis Sci 58, 1668–1675 (2013). https://doi.org/10.1007/s10620-012-2536-2

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  • DOI: https://doi.org/10.1007/s10620-012-2536-2

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