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Matrix Metalloproteinase-14 Is a Negative Prognostic Marker for Patients with Gastric Cancer

Digestive Diseases and Sciences volume 58, pages 1264–1270 (2013)Cite this article

Abstract

Background

Matrix metalloproteinase-14 (MMP-14) has been considered to play an important role in invasion and metastasis of human solid tumor.

Aim

The present study aimed to investigate the association of MMP-14 with overall survival in human gastric cancer.

Methods

Gastric cancer and adjacent normal specimens were collected from 205 patients who had not received neoadjuvant chemotherapy. MMP-14 expression was investigated by immunohistochemistry assay and staining evaluation results were analyzed statistically in relation to overall survival of patients.

Results

MMP-14 expression proved to be increased in gastric cancer compared with that in normal tissues. It was also proved that MMP-14 expression was associated with tumor invasion, metastasis, and TNM stage while no correlations were detected between MMP-14 expression and age, sex, differentiation status, or Lauren’s classification. Moreover, patients with gastric cancer of MMP-14-positive expression tend to have worse overall survival compared with those with MMP-14 negative expression.

Conclusions

The present study confirmed the over-expression of MMP-14 in human gastric cancer and its association with tumor progression. It also provided the first evidence that MMP-14 expression in gastric cancer was an independent negative prognostic factor of patients.

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Acknowledgments

This work was supported by the National Natural Science Foundation of China (No. 31270812).

Conflict of interest

None.

Author information

Affiliations

  1. Department of Gastrointestinal Surgery, State Key Laboratory of Cancer Biology, Xijing Hospital of Digestive Diseases, The Fourth Military Medical University, Xi’an, China

    Liang He, Dake Chu, Jianyong Zheng, Jipeng Li, Qingchuan Zhao & Gang Ji

  2. Department of General Surgery, Lanzhou Military District Hospital in Urumqi, Urumqi, Xinjiang, China

    Liang He

  3. Department of Biochemistry and Molecular Biology, State Key Laboratory of Cancer Biology, The Fourth Military Medical University, Xi’an, China

    Dake Chu

  4. Department of Neurosurgery, Xijing Hospital, The Fourth Military Medical University, Xi’an, China

    Xia Li

  5. Department of Emergency, Northern Hospital, Xi’an, China

    Shanhong Liu

Authors
  1. Liang He
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  2. Dake Chu
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  3. Xia Li
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  4. Jianyong Zheng
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  5. Shanhong Liu
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  6. Jipeng Li
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  7. Qingchuan Zhao
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  8. Gang Ji
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Corresponding author

Correspondence to Gang Ji.

Additional information

Liang He, Dake Chu, Xia Li, Jianyong Zheng, and Shanhong Liu contributed equally to this work.

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He, L., Chu, D., Li, X. et al. Matrix Metalloproteinase-14 Is a Negative Prognostic Marker for Patients with Gastric Cancer. Dig Dis Sci 58, 1264–1270 (2013). https://doi.org/10.1007/s10620-012-2513-9

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  • DOI: https://doi.org/10.1007/s10620-012-2513-9

Keywords

  • Matrix metalloproteinase-14
  • Gastric cancer
  • Immunohistochemistry
  • Prognosis