Donor-Transmitted Malignancy in a Liver Transplant Recipient: A Case Report and Review of Literature
Donor-transmitted malignancy is a rare complication of organ transplantation. This case illustrates a donor-transmitted adenocarcinoma in a patient 11 months after an orthotopic liver transplant for cryptogenic cirrhosis and hepatocellular carcinoma (HCC). Diagnosis of donor-transmitted malignancy may be challenging and can be confused with HCC recurrence. A timely diagnosis is crucial as a delay may limit treatment options. Biopsy of newly found liver lesions and the use of karyotypic and microsatellite analysis may be essential for diagnosis. Protocols should be in place to help recognize and limit the incidence of donor-transmitted malignancy.
KeywordsLiver transplant Donor-transmitted malignancy Microsatellite analysis Hepatocellular carcinoma
- 1.McPhaul JJ, McIntosh DA. Tissue transplantation still vexes. N Engl Med. 1965;272:105.Google Scholar
- 9.Detry O, Honore P, Jacquet N. Management of recipients of hepatic allografts harvested from donors with malignancy diagnosed shortly after transplantation. Clin Tranplant. 1998;12:579–581.Google Scholar
- 11.Gray BN, Anderson JE, Burton MA, et al. Regression of liver metastases following treatment with yttrium-90 microspheres. Aust NZ J Surg. 1992;62:105–110.Google Scholar
- 18.Organ Procurement and Transplantation Network (OPTN) and Scientific Registry of Transplant Recipients (SRTR). OPTN/SRTR 2010 Annual Data Report. Rockville, MD: Department of Health and Human Services, Health Resources and Services Administration, Healthcare Systems Bureau, Division of Transplantation; 2011.Google Scholar