Digestive Diseases and Sciences

, Volume 58, Issue 4, pp 1116–1124 | Cite as

MRI Prediction of Islet Yield for Autologous Transplantation After Total Pancreatectomy for Chronic Pancreatitis

  • Khalid M. Khan
  • Chirag S. Desai
  • Bobby Kalb
  • Charmi Patel
  • Brianna M. Grigsby
  • Tun Jie
  • Rainer W. G. Gruessner
  • Horacio Rodriguez-Rilo
Original Article



The relationship between magnetic resonance imaging (MRI), histopathology, and islet yield was examined for chronic pancreatitis patients undergoing total pancreatectomy and autologous islet cell transplant (TP-AIT) to determine if the yield can be predicted by pre-operative MRI.


MRI sequences and histopathology were scored and compared for patients from whom ≤2,500 islet equivalents/kg were obtained with those from whom >2,500 islet equivalents/kg were obtained.


Twenty patients, 14 female, mean age 40.20 ± 12.5 years, (range 19–63) underwent MRI before TP-AIT; mean 3,724 ± 891 islet equivalents/kg body weight, median 2,970, (range 76–17,770) were procured. There was no correlation between islet cell numbers and pancreas weight, HgbA1c, or c-peptide. The most common MRI sequence abnormality was the delayed interstitial phase, 14/18 (78 %). The other common MRI sequence abnormalities were, precontrast T1W 3D GRE sequence, 13/19 (68 %), and the arterial perfusion phase, 11/18 (61 %). The pancreatic duct was dilated in 10/20 (50 %). Parenchymal atrophy was noted in 10/20 (50 %). Median scores for individual MRI sequences were greater in patients with an islet cell yield of ≤2,500 islet equivalents/kg; for the delayed interstitial phase the difference was significant (median 2.5, range 1–3 versus median 0.5, range 0–3, P = 0.034). Histologically the most common feature was fibrosis, (17/17, 100 %); the score for fibrosis was greater for patients with an islet cell yield of ≤2,500 islet equivalents/kg (median 6.0, range 5–7 versus median 4.0, range 3–7, P = 0.024).


A diminished islet yield may be predicted on the basis of the delayed interstitial phase MRI sequence.


Delayed phase MRI Pancreatic fibrosis Autotransplantation 



Autologous islet transplant


Chronic pancreatitis

H &E

Hematoxylin and eosin


Magnetic resonance imaging


Portal vein


Total pancreatectomy


Conflict of interest



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Copyright information

© Springer Science+Business Media New York 2012

Authors and Affiliations

  • Khalid M. Khan
    • 1
    • 4
  • Chirag S. Desai
    • 1
    • 4
  • Bobby Kalb
    • 2
  • Charmi Patel
    • 3
  • Brianna M. Grigsby
    • 1
  • Tun Jie
    • 1
  • Rainer W. G. Gruessner
    • 1
  • Horacio Rodriguez-Rilo
    • 1
  1. 1.Departments of Surgery, College of MedicineUniversity of ArizonaTucsonUSA
  2. 2.Departments of RadiologyUniversity of ArizonaTucsonUSA
  3. 3.Departments of PathologyUniversity of ArizonaTucsonUSA
  4. 4.Transplant Institute MedStar Georgetown University HospitalWashingtonUSA

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