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Clinical Characteristics and the Expression Profiles of Inflammatory Cytokines/Cytokine Regulatory Factors in Asymptomatic Patients with Nodular Gastritis

Digestive Diseases and Sciences volume 57, pages 1486–1495 (2012)Cite this article

Abstract

Background

Nodular gastritis (NG) has been reported in adult dyspeptic patients, whereas information on NG in asymptomatic patients is limited.

Aims

To evaluate the prevalence, clinico-epidemiological characteristics, and expression profiles of inflammatory cytokines or cytokine regulatory factors of NG in asymptomatic adults.

Methods

A cross-sectional study was conducted prospectively using 2,579 consecutive asymptomatic subjects who underwent screening esophagogastroduodenoscopy. The expression of inflammatory cytokines or cytokine regulatory factors in the gastric mucosa of NG patients was evaluated using immunofluorescence staining.

Results

NG was diagnosed in 52 patients (2.0%) and showed a predilection for females (M:F = 1:1.89) and young adults (median age: 34 years; range: 25–51 years). All NG patients were positive for Helicobacter pylori infection. Based on multivariate analysis, the risk of NG was increased in patients younger than 40 years (OR, 7.57; 95% CI, 3.76–15.24) and of the female gender (OR, 2.12; 95% CI; 1.05–4.28). Immunofluorescent staining for interleukin (IL)-1β, IL-10, IL-18, IL-18 binding protein, IL-32, IL-33, and neutrophil proteinase 3 (PR3) was performed on cryosections of gastric mucosa. Interestingly, the expression of PR3 was highly increased in the gastric biopsies from asymptomatic NG patients but was expressed infrequently in the controls.

Conclusions

Asymptomatic NG is associated with H. pylori infection, and a predilection for this condition exists in young females. The PR3 expression of gastric mucosa might play an important role in the pathogenesis of NG.

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Acknowledgment

This paper was supported by Konkuk University in 2009.

Conflict of interest

No conflicts of interest exist.

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Affiliations

  1. Department of Internal Medicine, Konkuk University School of Medicine, 4-12 Hwayang-dong, Gwangjin-gu, Seoul, 143-729, Republic of Korea

    Sung Noh Hong, Ju Hyun Jang, Soo Young Ahn, Jeong Hwan Kim, Won Hyeok Choe, Sun-Young Lee, In Kyung Sung, Hyung Seok Park & Chan Sup Shim

  2. Department of Biomedical Science and Technology, Medical Immunology Center, Konkuk University, Seoul, Korea

    Sung Noh Hong, Seunghyun Jo, Jida Choi, Soohyun Kim & Jeong Hwan Kim

Authors
  1. Sung Noh Hong
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  2. Seunghyun Jo
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Correspondence to Sung Noh Hong or Soohyun Kim.

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Sung Noh Hong and Seunghyun Jo contributed equally to this work.

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Hong, S.N., Jo, S., Jang, J.H. et al. Clinical Characteristics and the Expression Profiles of Inflammatory Cytokines/Cytokine Regulatory Factors in Asymptomatic Patients with Nodular Gastritis. Dig Dis Sci 57, 1486–1495 (2012). https://doi.org/10.1007/s10620-012-2053-3

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Keywords

  • Helicobacter pylori
  • Gastritis
  • Nodular gastritis
  • Cytokines
  • Neutrophil proteinase 3