Abstract
Background
Hepatitis C virus (HCV) is a common and expensive infectious disease. The current standard of care for HCV infection, pegylated interferon with ribavirin (PEG–RBV), is costly and has a significant adverse event profile.
Aim
To quantify the direct economic burden of HCV infection and PEG–RBV treatment for HCV.
Methods
Using a large administrative claims database, we evaluated the medical and prescription drug costs of patients with HCV from 2002 to 2007. A cohort of patients with PEG–RBV was 1:1 propensity score-matched to a cohort of untreated HCV patients. Multivariate models adjusted for demographic and clinical characteristics in evaluating the effect of PEG–RBV treatment on direct medical expenditure.
Results
The matched analysis included 20,002 patients. PEG–RBV-treated patients had higher total direct medical costs ($28,547 vs. $21,752; P < 0.001), outpatient pharmacy costs ($17,419 vs. $2,900; P < 0.001), and outpatient physician visit costs ($894 vs. $787; P < 0.001), but lower inpatient costs ($3,942 vs. $9,543; P < 0.001) and emergency room costs ($366 vs. $505; P < 0.001). After multivariate adjustment, PEG–RBV use was associated with an additional $9,423 in total direct medical costs and an additional $12,244 in HCV-related total medical costs.
Conclusion
Total HCV-related medical costs are higher for treated than untreated patients, driven mostly by higher outpatient pharmacy costs, which outweigh higher HCV-related inpatient costs incurred by untreated patients.
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Conflict of interest
This study was funded in full by Human Genome Sciences and Novartis Pharmaceuticals Corporation, which employs Cynthia Beam and Paula Chakravarti, respectively. Thomson Reuters was awarded a contract to conduct the study and is the employer of Machaon Bonafede, Katy Pan, and Kathleen Wilson. Brennan Spiegel and Matthew Solomon received funding from Human Genome Sciences to serve as consultants in support of the study.
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Solomon, M., Bonafede, M., Pan, K. et al. Direct Medical Care Costs Among Pegylated Interferon Plus Ribavirin-Treated and Untreated Chronic Hepatitis C Patients. Dig Dis Sci 56, 3024–3031 (2011). https://doi.org/10.1007/s10620-011-1802-z
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DOI: https://doi.org/10.1007/s10620-011-1802-z