Digestive Diseases and Sciences

, Volume 56, Issue 9, pp 2742–2749 | Cite as

Prospective Evaluation of FibroScan for the Diagnosis of Hepatic Fibrosis Compared with Liver Biopsy/AST Platelet Ratio Index and FIB-4 in Patients with Chronic HBV Infection

  • Xia Zhu
  • Li-Chun Wang
  • En-Qiang Chen
  • Xue-Bing Chen
  • Li-Yu Chen
  • Li Liu
  • Xue-Zhong Lei
  • Cong Liu
  • Hong TangEmail author
Original Article



The FibroScan (FS), the aspartate aminotransferase-to-platelet ratio index (APRI), and the FIB-4 index are simple and inexpensive methods to detect liver fibrosis.


The primary objective was to evaluate the performance of FS for the noninvasive diagnosis of hepatic fibrosis in Western Chinese patients with chronic hepatitis B virus (HBV) infection compared with APRI and FIB-4; the secondary objective was to determine liver stiffness measurement (LSM) cutoff values for the noninvasive diagnosis of significant fibrosis and liver cirrhosis.


Overall, 175 consecutive patients with chronic HBV infection, successful liver biopsy, and alanine aminotransferase levels ≤2× ULN were prospectively studied. Liver fibrosis was graded by an independent pathologist using the METAVIR (F0–F4) classification. APRI and FIB-4 were calculated from laboratory data.


The area under receiver operating characteristics curves (AUROC) for LSM for significant fibrosis (METAVIR F2–3) and cirrhosis (F4) was 0.95 (95% confidence interval, 0.91–0.98) and 0.98 (0.96–0.99), respectively. For the detection of significant fibrosis and cirrhosis, the AUROC of APRI were 0.81 (0.74–0.87) and 0.83 (0.77–0.90); the AUROC of FIB-4 were 0.86 (0.80–0.91) and 0.77 (0.68–0.85). FS optimal cutoff values for the identification of significant fibrosis and cirrhosis were 7.9 and 13.8 kPa, respectively.


FS is a reliable predictor of significant fibrosis and cirrhosis in Western Chinese patients with chronic HBV infection, and is superior to APRI and FIB-4. FS cutoff values could be considered as clinical reference for detecting significant fibrosis and cirrhosis.


APRI Chronic HBV infection FIB-4 FibroScan Liver biopsy 



We wish to thank all patients who participated in the study. We also thank Prof. Li-Chun Wang and Bing-Jun Lei (Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, China) who agreed to have their patients participate in this study. This work was financially supported by the National Key Technologies Research and Development Program of China during the 11th Five-Year Plan Period (No.2008ZX10002-006), National S&T Major Project for Infections Diseases Control (No.2009ZX10004-905), and the National Basic Research Program of China (No.2007CB512902).


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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Xia Zhu
    • 1
    • 2
  • Li-Chun Wang
    • 1
    • 2
  • En-Qiang Chen
    • 1
    • 2
  • Xue-Bing Chen
    • 1
    • 2
  • Li-Yu Chen
    • 1
    • 2
  • Li Liu
    • 1
    • 2
  • Xue-Zhong Lei
    • 1
    • 2
  • Cong Liu
    • 1
    • 2
  • Hong Tang
    • 1
    • 2
    Email author
  1. 1.Center of Infectious DiseasesWest China Hospital of Sichuan UniversityWu Hou District, ChengduChina
  2. 2.Division of Infectious Diseases, State Key Laboratory of BiotherapySichuan UniversityChengduChina

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