Skip to main content

Advertisement

Log in

Isolated Aspartate Aminotransferase Elevation: Think Macro-AST

  • Stanford Multidisciplinary Seminars
  • Published:
Digestive Diseases and Sciences Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Subscribe and save

Springer+ Basic
$34.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or eBook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. Giannini EG, Testa R, Savarino V. Liver enzyme alteration: a guide for clinicians. CMAJ. 2005;175:367–379.

    Google Scholar 

  2. Turecky L. Macroenzymes and their clinical significance. Bratisl Lek Listy. 2004;105:260–263.

    CAS  PubMed  Google Scholar 

  3. Galasso PJ, Litin SC, O’Brien JF. The macroenzymes: a clinical review. Mayo Clin Proc. 1993;68:349–354.

    CAS  PubMed  Google Scholar 

  4. Remaley AT, Wilding P. Macroenzymes: biochemical characterization, clinical significance, and laboratory detection. Clin Chem. 1989;35:2261–2270.

    CAS  PubMed  Google Scholar 

  5. Sturk A, Sanders GT. Macro enzymes: prevalence, composition, detection and clinical relevance. J Clin Chem Clin Biochem. 1990;28:65–81.

    CAS  PubMed  Google Scholar 

  6. Lee KN, Csako G, Bernhardt P, et al. Relevance of macro creatine kinase type 1 and type 2 isoenzymes to laboratory and clinical data. Clin Chem. 1994;40:1278–1283.

    CAS  PubMed  Google Scholar 

  7. Briani C, Zaninotto M, Forni M, et al. Macroenzymes: too often overlooked. J Hepatol. 2003;38:119.

    Article  PubMed  Google Scholar 

  8. Sass DA, Chadalavada R, Virji MA. Unexplained isolated elevation in serum aspartate aminotransferase: think macro! Am J Med. 2007;120:e5–e6.

    Article  PubMed  Google Scholar 

  9. Asanuma K, Yagihashi A, Watanabe N. Characterization of the aspartate aminotransferase-immunoglobulin M complex in a Japanese woman. Clin Chem. 1997;43:686–687.

    CAS  PubMed  Google Scholar 

  10. Triester SL, Douglas DD. Development of macro-aspartate aminotransferase in a patient undergoing specific allergen injection immunotherapy. Am J Gastroenterol. 2005;100:243–245.

    Article  PubMed  Google Scholar 

  11. Werner T, Vargas HE, Chalasani N. Macro-aspartate aminotransferase and monoclonal gammopathy: a review of two cases. Dig Dis Sci. 2007;52:1197–1198.

    Article  PubMed  Google Scholar 

  12. Chung YW, Sohn JH, Baek CH, et al. Macro-aspartate aminotransferase in a patient with chronic hepatitis C. Korean J Gastroenterol. 2006;47:229–232.

    PubMed  Google Scholar 

  13. Collins J, Ritter D, Bacon BR, et al. Macro-aspartate aminotransferase in a female with antibodies to hepatitis C virus. Liver. 2002;22:501–506.

    Article  PubMed  Google Scholar 

  14. Zaman Z, Van Orshoven A, Marien G, et al. Simultaneous macroamylasemia and macrolipasemia. Clin Chem. 1994;40:939–942.

    CAS  PubMed  Google Scholar 

  15. Orlando R, Lirussi F. Macro-aspartate aminotransferase and pregnancy: any influence? Eur J Gastroenterol Hepatol. 2004;16:717–718.

    Article  PubMed  Google Scholar 

  16. Sion JP, Laureys M, Gerlo E, et al. Detection of macroenzymes in serum by high-performance gel permeation chromatography. J Chromatogr. 1989;496:91–100.

    Article  CAS  PubMed  Google Scholar 

  17. Mifflin TE, Bruns DE. University of Virginia case conference. Macroamylase, macro creatine kinase, and other macroenzymes. Clin Chem. 1985;31:1743–1748.

    CAS  PubMed  Google Scholar 

  18. Davidson DF, Watson DJM. Macroenzyme detection by polyethylene glycol precipitation. Ann Clin Biochem. 2003;40:514–520.

    Article  CAS  PubMed  Google Scholar 

  19. Orlando R, Carbone A, Lirussi F. Macro-aspartate aminotransferase (macro-AST). A 12-year follow-up study in a young female. Eur J Gastroenterol Hepatol. 2003;15:1371–1373.

    Article  PubMed  Google Scholar 

  20. Caropreso M, Fortunato G, Lenta S, et al. Prevalence and long-term course of macro-aspartate aminotransferase in children. J Pediatr. 2009;154:744–748.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Emmet B. Keeffe.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lee, M., Vajro, P. & Keeffe, E.B. Isolated Aspartate Aminotransferase Elevation: Think Macro-AST. Dig Dis Sci 56, 311–313 (2011). https://doi.org/10.1007/s10620-011-1575-4

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10620-011-1575-4

Keywords

Navigation