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A Double-Layered (Comvi) Self-Expandable Metal Stent for Malignant Gastroduodenal Obstruction: A Prospective Multicenter Study

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Abstract

Background

A self-expandable metal stent (SEMS) has emerged as an effective palliative treatment for malignant gastroduodenal obstruction resulting from gastric or periampullary malignancy. Despite the stent’s effectiveness, tumor ingrowth and stent migration remain complications requiring reintervention. The purpose of this study was to evaluate the efficacy and safety of a double-layered SEMS (Comvi).

Methods

We performed a prospective multicenter study in two university hospitals and two referral hospitals. In fifty consecutive patients with malignant gastroduodenal obstructions, placement of double-layered SEMS, comprising an outer uncovered stent and an inner covered stent that overlap each other, was performed. Palliation, efficacy, and incidence of complications were evaluated.

Results

Technical and clinical success was achieved in 100 and 88% of patients, respectively. There were no procedure-related complications. Five patients experienced stent migration (10%). For four of five patients’ stent migration occurred within two weeks of stent placement. Stent collapse occurred in five patients after one month. Reintervention for stent migration, collapse, or tumor overgrowth was required for 14 (28%) patients.

Conclusions

Endoscopic placement of a double-layered stent is a safe and effective modality for the palliation of malignant gastroduodenal obstruction. However, considering reintervention, this stent does not seem to add any clear advantage compared with preexisting uncovered stents. Migration, especially within the first two weeks, and stent collapse are still unresolved problems. The device should be fixed or the design modified to reduce these problems.

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Acknowledgments

Supported by a grant from the Korea Healthcare Technology R&D Project, Ministry for Health, Welfare & Family Affairs, Republic of Korea (A091047).

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Author notes

  1. Yong Wuk Kim, Cheol Woong Choi, Dae Hwan Kang, Hyung Wook Kim, Chung Uk Chung, Dong Uk Kim, Su Bum Park, Kee Tae Park, Suk Kim, Eul Jo Jeung & Yong Mok Bae

    Present address: Department of Gastroenterology, Pusan National University School of Medicine and Medical Research Institute, Yangsan Medical Center, Yangsan, South Korea

Authors and Affiliations

  1. Department of Internal Medicine, Pusan National University School of Medicine and Medical Research Institute, Beomeo-ri, Mulgeum-eup, Yangsan-si, Gyeongsangnam-do, 626-770, South Korea

    Yong Wuk Kim, Cheol Woong Choi, Dae Hwan Kang, Hyung Wook Kim, Chung Uk Chung, Dong Uk Kim, Su Bum Park, Kee Tae Park, Suk Kim, Eul Jo Jeung & Yong Mok Bae

  2. Busan Medical Center, Pusan, South Korea

    Dong Uk Kim, Su Bum Park & Kee Tae Park

  3. Department of Radiology, Busan Medical Center, Pusan, South Korea

    Suk Kim

  4. Department of Gastroenterology, Daedong Hospital, Pusan, South Korea

    Yong Wuk Kim & Yong Mok Bae

  5. Department of Gastroenterology, Korea Hospital, Jinju, South Korea

    Eul Jo Jeung

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  1. Yong Wuk Kim
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Corresponding author

Correspondence to Dae Hwan Kang.

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Kim, Y.W., Choi, C.W., Kang, D.H. et al. A Double-Layered (Comvi) Self-Expandable Metal Stent for Malignant Gastroduodenal Obstruction: A Prospective Multicenter Study. Dig Dis Sci 56, 2030–2036 (2011). https://doi.org/10.1007/s10620-011-1566-5

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  • DOI: https://doi.org/10.1007/s10620-011-1566-5

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