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Polymorphisms in Interleukin-1B (IL-1B) and Interleukin 1 Receptor Antagonist (IL-1RN) Genes Associate with Gastric Cancer Risk in the Chinese Population

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Abstract

Background

Gastric cancer is one of the most common malignancies afflicting the Chinese population. Polymorphisms in interleukin-1B (IL-1B) and interleukin-1 receptor antagonist (IL-1RN) genes have been associated with increased gastric cancer risk.

Aims

A case–control study enrolled 392 gastric cancer patients and 508 healthy were carried out to investigate the association between polymorphisms in IL-1B and IL-1RN and gastric cancer risk.

Methods

Polymerase chain reaction (PCR)-restriction fragment length polymorphism was used for detection of two potentially functional polymorphisms (IL-1B-31 and IL-1B-511) in the IL-1B gene promoter and PCR was used for detection of the variable tandem repeat in the second intron of IL-1RN.

Results

The data showed that the IL-1B-31CC genotype increased gastric cancer risk to an adjusted odd of 2.27 (95% CI, 1.49–3.46), IL-1B-31CT to 1.48 (95% CI, 1.01–2.16) and IL-1B-31CT/CC to 1.68 (95% CI, 1.17–2.40), while IL-1B-51TT genotype associated with increased gastric cancer risk to an adjusted odd of 2.53 (95% CI, 1.67–3.84), IL-1B-511TC to 1.45 (95% CI, 1.02–2.06), and IL-1B-511TC TT/TC to 1.72 (95% CI, 1.23, 2.39). Furthermore, IL-1RN heterogeneity genotype (IL-1RN2L) was associated with gastric cancer risk to an adjusted odd of 1.70 (95% CI, 1.05–2.74) compared to the wild-type homozygote (IL-1RNLL). In addition, H. pylori infection enhanced gastric cancer risk through these SNPs.

Conclusions

The data from the current study demonstrated that the genotype CC or CT of IL-1B-31, TT or CT of IL-1B-511, and 2L of IL-1RN increased risk of gastric cancer in this Chinese population and the risk was further enhanced by H. pylori.

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Abbreviations

IL-1B:

Interleukin-1B

IL-1RN:

Interleukin-1 receptor antagonist

H. pylori :

Helicobacter pylori

PCR-RFLP:

Polymerase chain reaction-restriction fragment length polymorphism

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Acknowledgments

This study was supported in part by a grant from the Technology Development Program of Nanjing Medical University, Jiangsu Province, China (08NMUM107).

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Authors and Affiliations

  1. The Central Laboratory, Nanjing First Hospital Affiliated to Nanjing Medical University, 210006, Nanjing, China

    Bang-Shun He, Yu-Qin Pan, Yong-Fei Xu, Chan Zhu, Li-Li Qu & Shu-Kui Wang

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  1. Bang-Shun He
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Correspondence to Shu-Kui Wang.

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He, BS., Pan, YQ., Xu, YF. et al. Polymorphisms in Interleukin-1B (IL-1B) and Interleukin 1 Receptor Antagonist (IL-1RN) Genes Associate with Gastric Cancer Risk in the Chinese Population. Dig Dis Sci 56, 2017–2023 (2011). https://doi.org/10.1007/s10620-010-1557-y

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