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Lack of Grafted Liver Rejuvenation in Adult-to-Pediatric Liver Transplantation

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Abstract

Background

A grafted donor liver should grow and survive under the different conditions presented by a liver transplantation recipient. It has remained unclear, however, whether the age of a grafted liver can be modulated by recipient factors.

Aims

This study investigated whether a grafted aged donor liver can be rejuvenated in a pediatric recipient.

Methods

Of 119 living donor liver transplants, ten pairs were adult-to-pediatric combinations. Senescence marker protein-30 (SMP-30), which is a protein that is remarkably reduced upon aging, was used as a senescence marker. Immunohistochemical staining for SMP-30 was performed in biopsy specimen after living donor liver transplantation (LDLT). Re-expression of SMP-30 was investigated in a biopsied adult liver (n = 6) that had been transplanted in a pediatric recipient.

Results

A remarkable expression of SMP-30 was seen in a control pediatric normal liver in comparison with that in an aged adult donor biopsy. Re-expression or an increase in SMP-30 was not observed in the liver of any pediatric recipient who had received an adult liver.

Conclusion

An adult grafted liver does not appear to rejuvenate in a pediatric recipient.

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Authors and Affiliations

  1. Department of Surgery, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan

    Susumu Eguchi, Mitsuhisa Takatsuki, Masaaki Hidaka, Akihiko Soyama, Izumi Muraoka, Tetsuo Tomonaga & Takashi Kanematsu

  2. Investigative Pathology, Unit of Basic Medical Science, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, Japan

    Isao Shimokawa

Authors
  1. Susumu Eguchi
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  2. Mitsuhisa Takatsuki
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  3. Masaaki Hidaka
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  4. Akihiko Soyama
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  5. Izumi Muraoka
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  6. Tetsuo Tomonaga
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  7. Isao Shimokawa
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  8. Takashi Kanematsu
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Correspondence to Susumu Eguchi.

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Eguchi, S., Takatsuki, M., Hidaka, M. et al. Lack of Grafted Liver Rejuvenation in Adult-to-Pediatric Liver Transplantation. Dig Dis Sci 56, 1542–1547 (2011). https://doi.org/10.1007/s10620-010-1445-5

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  • DOI: https://doi.org/10.1007/s10620-010-1445-5

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