Abstract
Aim
The aim of this study is to evaluate the diagnostic yield of capsule endoscopy in nonsteroidal anti-inflammatory drug (NSAID)-induced enteropathy in pigs.
Materials and Methods
Indomethacin (400 mg/day) was administrated orally for 10 days to eight female pigs weighing 36.3 ± 2.4 kg. Afterwards, capsule endoscopy was performed, using the EndoCapsule system (Olympus Optical Co., Tokyo, Japan). The following morning, pharmacological euthanasia and immediate autopsy were performed.
Results
Small bowel injury compatible with NSAID-induced enteropathy was observed in 7/8 animals. The most common lesions were red spots and erosions. Ulcers and small intestinal bleeding were identified sporadically. Sensitivity and specificity of capsule endoscopy were 83.3% and 95.8%, respectively.
Conclusion
Our results indicate that wireless capsule endoscopy is a highly accurate noninvasive method for evaluation of experimental NSAID-induced enteropathy.
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Acknowledgments
The authors are grateful to the endoscopy nurses Mrs. Sylva Cvejnová, Mrs. Ludmila Pavlatová, Mrs. Hana Klusáková, and Mrs. Milada Veldová for their excellent technical assistance. The endoscopic part of the study was supported by research project MZO 00179906 from the Ministry of Health, Czech Republic. The experimental part of the study was supported by research grant GAČR 305/08/0535, Czech Republic. None of the authors have any financial interests to disclose.
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Tachecí, I., Květina, J., Bureš, J. et al. Wireless Capsule Endoscopy in Enteropathy Induced by Nonsteroidal Anti-inflammatory Drugs in Pigs. Dig Dis Sci 55, 2471–2477 (2010). https://doi.org/10.1007/s10620-009-1066-z
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DOI: https://doi.org/10.1007/s10620-009-1066-z