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Wireless Capsule Endoscopy in Enteropathy Induced by Nonsteroidal Anti-inflammatory Drugs in Pigs

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Abstract

Aim

The aim of this study is to evaluate the diagnostic yield of capsule endoscopy in nonsteroidal anti-inflammatory drug (NSAID)-induced enteropathy in pigs.

Materials and Methods

Indomethacin (400 mg/day) was administrated orally for 10 days to eight female pigs weighing 36.3 ± 2.4 kg. Afterwards, capsule endoscopy was performed, using the EndoCapsule system (Olympus Optical Co., Tokyo, Japan). The following morning, pharmacological euthanasia and immediate autopsy were performed.

Results

Small bowel injury compatible with NSAID-induced enteropathy was observed in 7/8 animals. The most common lesions were red spots and erosions. Ulcers and small intestinal bleeding were identified sporadically. Sensitivity and specificity of capsule endoscopy were 83.3% and 95.8%, respectively.

Conclusion

Our results indicate that wireless capsule endoscopy is a highly accurate noninvasive method for evaluation of experimental NSAID-induced enteropathy.

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Acknowledgments

The authors are grateful to the endoscopy nurses Mrs. Sylva Cvejnová, Mrs. Ludmila Pavlatová, Mrs. Hana Klusáková, and Mrs. Milada Veldová for their excellent technical assistance. The endoscopic part of the study was supported by research project MZO 00179906 from the Ministry of Health, Czech Republic. The experimental part of the study was supported by research grant GAČR 305/08/0535, Czech Republic. None of the authors have any financial interests to disclose.

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Authors and Affiliations

  1. Second Department of Internal Medicine, Charles University in Praha, Faculty of Medicine at Hradec Králové, University Teaching Hospital, Hradec Králové, Czech Republic

    Ilja Tachecí, Jan Bureš, Stanislav Rejchrt & Marcela Kopáčová

  2. Institute of Experimental Biopharmaceutics, Joint Research Centre of Czech Academy of Sciences and PRO.MED.CS Praha a.s, Hradec Králové, Czech Republic

    Jaroslav Květina & Martin Kuneš

  3. Department of Radiobiology, Faculty of Military Health Sciences, University of Defence, Hradec Králové, Czech Republic

    Jan Österreicher, Jaroslav Pejchal & Stanislav Špelda

Authors
  1. Ilja Tachecí
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  2. Jaroslav Květina
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  3. Jan Bureš
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  4. Jan Österreicher
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  5. Martin Kuneš
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  6. Jaroslav Pejchal
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  7. Stanislav Rejchrt
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  9. Marcela Kopáčová
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Correspondence to Ilja Tachecí.

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Tachecí, I., Květina, J., Bureš, J. et al. Wireless Capsule Endoscopy in Enteropathy Induced by Nonsteroidal Anti-inflammatory Drugs in Pigs. Dig Dis Sci 55, 2471–2477 (2010). https://doi.org/10.1007/s10620-009-1066-z

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  • DOI: https://doi.org/10.1007/s10620-009-1066-z

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