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RETRACTED ARTICLE: EpCAM: A Potential Antimetastatic Target for Gastric Cancer

Digestive Diseases and Sciences volume 55, pages 2165–2171 (2010)Cite this article

This article was retracted on 28 May 2013

Abstract

Purpose

Epithelial cellular adhesion molecule (EpCAM) is an attractive immunotherapeutic target to overcome metastasis of a variety of epithelium-oriented cancers. Edrecolomab, one kind of EpCAM monoclonal antibody (Panorex®), has been approved for clinical application as postoperative adjuvant therapy in breast and colorectal cancer. However, the role of EpCAM in gastric cancer metastasis remains unclear.

Results

EpCAM was found to be more highly overexpressed in metastatic gastric cancer than in nonmetastatic samples by immunohistochemistry staining. The expression level of EpCAM in gastric cancer cell lines was determined by reverse-transcription polymerase chain reaction (RT-PCR) and Western blotting, respectively. Downregulation of EpCAM by small interfering RNA (siRNA) significantly suppressed in vitro adhesive, invasive, and migratory and in vivo metastatic abilities of gastric cancer cells.

Conclusion

We provide first evidence that EpCAM contributes to the migration of gastric cancer, suggesting that EpCAM-targeted therapy might be a promising strategy in metastatic gastric cancer.

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Acknowledgments

This work was supported by grants from the National Natural Science Foundation of China (No. 30670969).

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Affiliations

  1. State Key Laboratory of Cancer Biology, Digestive Diseases of Xijing Hospital, Fourth Military Medical University, 15 Changle Western Road, 710032, Xi’an, Shaanxi Province, People’s Republic of China

    Wenqi Du, Shanshan Cao, Li Wang, Feihu Bai, Jie Liu & Daiming Fan

  2. Department of Digestive Diseases, Nanjing General Hospital of Nanjing Military Command, PLA, 210002, Nanjing, Jiangsu Province, People’s Republic of China

    Hongzan Ji

  3. Department of Digestive Diseases, Huashan Hospital, Fudan University, 200040, Shanghai, People’s Republic of China

    Jie Liu

Authors
  1. Wenqi Du
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  2. Hongzan Ji
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  3. Shanshan Cao
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  4. Li Wang
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  5. Feihu Bai
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  6. Jie Liu
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  7. Daiming Fan
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Corresponding author

Correspondence to Jie Liu.

Additional information

This article was retracted as it plagiarized content from the following article: "EpCAM is overexpressed in gastric cancer and its downregulation suppresses proliferation of gastric cancer" by Du Wenqi, Wang Li , Cao Shanshan, Chen Bei, Zhang Yafei, Bai Feihu, Liu Jie, Fan Daiming published online on March 18, 2009 by Journal of Cancer Research and Clinical Oncology, DOI http://dx.doi.org/10.1007/s00432-009-0569-5.

The retraction note to this article can be found online at http://dx.doi.org/10.1007/s10620-013-2722-x.

Wenqi Du and Hongzan Ji contributed equally to this work.

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Du, W., Ji, H., Cao, S. et al. RETRACTED ARTICLE: EpCAM: A Potential Antimetastatic Target for Gastric Cancer. Dig Dis Sci 55, 2165–2171 (2010). https://doi.org/10.1007/s10620-009-1033-8

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  • DOI: https://doi.org/10.1007/s10620-009-1033-8

Keywords

  • EpCAM (epithelial cellular adhesion molecule)
  • Gastric cancer
  • Metastasis
  • Small interfering RNA (siRNA)