Severe Cholestasis and Renal Failure Associated with the Use of the Designer Steroid Superdrol™ (Methasteron™): A Case Report and Literature Review

This is a preview of subscription content, access via your institution.

Fig. 1
Fig. 2
Fig. 3
Fig. 4



Androgenic/anabolic steroids


Over the counter


  1. 1.

    Parkinson AB, Evans NA. Anabolic androgenic steroids: a survey of 500 users. Med Sci Sports Exerc. 2006;38:644–651. doi:10.1249/01.mss.0000210194.56834.5d.

    PubMed  Article  CAS  Google Scholar 

  2. 2.

    Handelsman DJ, Gupta L. Prevalence and risk factors for anabolic-androgenic steroid abuse in Australian high school students. Int J Androl. 1997;20:159–164. doi:10.1046/j.1365-2605.1997.d01-285.x.

    PubMed  Article  CAS  Google Scholar 

  3. 3.

    Stimac D, Milic S, Dintinjana RD, Kovac D, Ristic S. Androgenic/anabolic steroid-induced toxic hepatitis. J Clin Gastroenterol. 2002;35:350–352. doi:10.1097/00004836-200210000-00013.

    PubMed  Article  Google Scholar 

  4. 4.

    Hartgens F, Kuipers H. Effects of androgenic-anabolic steroids in athletes. Sports Med. 2004;34:513–554. doi:10.2165/00007256-200434080-00003.

    PubMed  Article  Google Scholar 

  5. 5.

    Jasiurkowski B, Raj J, Wisinger D, Carlson R, Zou L, Nadir A. Cholestatic jaundice and IgA nephropathy induced by OTC muscle building agent superdrol. Am J Gastroenterol. 2006;101:2659–2662.

    PubMed  CAS  Google Scholar 

  6. 6.

    Maravelias C, Dona A, Stefanidou M, et al. Adverse effects of anabolic steroids in athletes. A constant threat. Toxicol Lett. 2005;158:167–175. doi:10.1016/j.toxlet.2005.06.005.

    PubMed  Article  CAS  Google Scholar 

  7. 7.

    Sanchez-Osorio M, Duarte-Rojo A, Martinez-Benitez B, Torre A, Uribe M. Anabolic-androgenic steroids and liver injury. Liver Int. 2007; Epub ahead of print.

  8. 8.

    Orr R, Fiatorone Singh M. The anabolic androgenic steroid oxandrolone in the treatment of wasting and catabolic disorders: review of efficacy and safety. Drugs. 2004;64:725–750. doi:10.2165/00003495-200464070-00004.

    PubMed  Article  CAS  Google Scholar 

  9. 9.

    Murphy KD, Thomas S, Mlcak RP, Chinkes DL, Klein GL, Herndon DN. Effects of long-term oxandrolone administration in severely burned children. Surgery. 2004;136:219–224. doi:10.1016/j.surg.2004.04.022.

    PubMed  Article  Google Scholar 

  10. 10.

    Hall RC, Hall RC. Abuse of supraphysiologic doses of anabolic steroids. South Med J. 2005;98:550–555. doi:10.1097/01.SMJ.0000157531.04472.B2.

    PubMed  Article  Google Scholar 

  11. 11.

    Bagheri SA, Boyer JL. Peliosis hepatis associated with androgenic-anabolic steroid therapy. A severe form of hepatic injury. Ann Intern Med. 1974;81:610–618.

    PubMed  CAS  Google Scholar 

  12. 12.

    Socas L, Zumbado M, Pérez-Luzardo O, Ramos A, Pérez C, Hernández JR. Hepatocellular adenomas associated with anabolic androgenic steroid abuse in bodybuilders: a report of two cases and a review of the literature. Br J Sports Med. 2005;39:e27. doi:10.1136/bjsm.2004.013599.

    PubMed  Article  CAS  Google Scholar 

  13. 13.

    Carrasco D, Prieto M, Pallardó L, et al. Multiple hepatic adenomas after long-term therapy with testosterone enanthate. Review of the literature. J Hepatol. 1985;1:573–578. doi:10.1016/S0168-8278(85)80001-5.

    PubMed  Article  CAS  Google Scholar 

  14. 14.

    Gurakar A, Caraceni P, Fagiuoli S, Van Thiel DH. Androgenic/anabolic steroid-induced cholestasis: a review with four additional case reports. J Okla State Med Assoc. 1994;87:399–404.

    PubMed  CAS  Google Scholar 

  15. 15.

  16. 16.

    Bonetti A, Tirelli F, Catapano A, Dazzi D, Dei Cas A, Solito F, et al. Side effects of anabolic androgenic steroids abuse. Int J Sports Med. 2007; Epub ahead of print.

Download references

Author information



Corresponding author

Correspondence to Jawad Ahmad.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Nasr, J., Ahmad, J. Severe Cholestasis and Renal Failure Associated with the Use of the Designer Steroid Superdrol™ (Methasteron™): A Case Report and Literature Review. Dig Dis Sci 54, 1144–1146 (2009).

Download citation


  • Cholestasis
  • Naltrexone
  • Nutritional Supplement
  • Ursodeoxycholic Acid
  • Peliosis Hepatis