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Effect of Preoperative Intravenous Pantoprazole in Elective-Surgery Patients: A Pilot Study

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Abstract

Background This study evaluated the effects of intravenous pantoprazole on gastric volume and acid output in elective-surgical patients. Methods This is a multicenter, randomized, pilot study of adult patients receiving intravenous pantoprazole: 40 mg every 24 h, 40 mg every 12 h (q12h) or 80 mg q12h. The first dose was administered 1 h before general anesthesia for surgery. All gastric fluid was aspirated through a nasogastric tube 1 h before dosing and through the postoperative period. Aspirate volume was recorded; pH and H+ concentrations were measured. Result Twenty-six patients were enrolled and 21 were evaluable. Pantoprazole was well tolerated. All regimens decreased gastric acid output and volume, and increased pH within 1 h of dosing. Effects were sustained for up to 12 h following single-dose administration. Conclusions Intravenous pantoprazole administered prior to anesthesia induction may be efficacious for the reduction of gastric volume and acid output, and for pulmonary aspiration prophylaxis in surgical patients.

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Acknowledgment

This study was funded by Wyeth Pharmaceuticals, Collegeville, PA. Conflicts-of-interest: Dr. David Oh—grant support from Wyeth; Dr. Joseph Pisegna—consultant, Grant Support from and Speaker for: Wyeth, Astra Zeneca, Takeda (TAP) and Novartis; Dr. Jeffrey Norton—none to disclose; Dr. Ronald Fogel—none to disclose; Jay Graepel and Mary Beth Dorr are currently and Robyn Karlstadt was formerly employed by Wyeth Pharmaceuticals.

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Authors and Affiliations

  1. CURE: Digestive Diseases Research Center, University of California, Los Angeles, CA, USA

    Joseph R. Pisegna & David S. Oh

  2. Division of Gastroenterology and Hepatology (691/111C), VA Greater Los Angeles Healthcare System, Los Angeles, CA, 90073, USA

    Joseph R. Pisegna & David S. Oh

  3. Department of Medicine, University of California, Los Angeles, CA, USA

    Joseph R. Pisegna & David S. Oh

  4. Global Medical Affairs, Wyeth Pharmaceuticals, Collegeville, PA, USA

    Robyn G. Karlstadt, G. Jay Graepel & Mary Beth Dorr

  5. Department of Surgery, Stanford University School of Medicine, San Francisco, CA, USA

    Jeffrey A. Norton

  6. Division of Gastroenterology, Henry Ford Health System, Detroit, MI, USA

    Ronald Fogel

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  1. Joseph R. Pisegna
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  2. Robyn G. Karlstadt
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  3. Jeffrey A. Norton
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  4. Ronald Fogel
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  5. David S. Oh
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  7. Mary Beth Dorr
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Correspondence to Joseph R. Pisegna.

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Pisegna, J.R., Karlstadt, R.G., Norton, J.A. et al. Effect of Preoperative Intravenous Pantoprazole in Elective-Surgery Patients: A Pilot Study. Dig Dis Sci 54, 1041–1049 (2009). https://doi.org/10.1007/s10620-008-0445-1

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  • DOI: https://doi.org/10.1007/s10620-008-0445-1

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