Abstract
A low curability of ulcers infected with Candida has been reported in the literature. The aim of the study reported here was to investigate experimentally whether Candida infection affects the healing of ulcers. Candida albicans (the Candida group) or saline (the control group) was administered intragastrically into rats with a cysteamine-induced duodenal ulcer. The duodenal lesions, vascular endothelial growth factor A (VEGF-A) and proliferating cell nuclear antigen (PCNA) were assessed. On Day 7 post-administration, 70.4% rats of the Candida group had a duodenal ulcer compared with 33.3% in the control group (P < 0.05). The duodenal ulcer in the Candida group was significantly larger and deeper than that in the control group. The number of VEGF-A- and PCNA-positive cells was smaller and the area of VEGF-A expression was lower in the Candida group. Using a rat model, we have demonstrated that Candida infection can delay the wound healing process of duodenal ulcers by means of a low expression of VEGF-A and PCNA.
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Acknowledgments
The encyclopedic duodenal ulcer knowledge of Professor Sandor Szabo (Professor of Pathology and Pharmacology, University of California at Irvine, and Chief of Staff, VA Long Beach Healthcare System, CA, USA) is gratefully acknowledged. The creation of the experimental model in the present study was also directed by Professor Szabo. We also thank Miss. Chika Fukushima for her great assistance in performing this experimental work.
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Jin, L., Yoshida, M., Nakamura, T. et al. Candida albicans Infection Delays Duodenal Ulcer Healing in Cysteamine-Induced Duodenal Ulcers in Rats. Dig Dis Sci 53, 2878–2885 (2008). https://doi.org/10.1007/s10620-008-0385-9
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DOI: https://doi.org/10.1007/s10620-008-0385-9