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Partially Hydrolyzed Guar Gum Attenuates the Severity of Pouchitis in a Rat Model of Ileal J Pouch-Anal Anastomosis

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Abstract

We aimed to evaluate the efficacy of treatment with partially hydrolyzed guar gum (PHGG) using a rat model of ileal pouch-anal anastomosis and pouchitis. In the J pouch groups, tissue myeloperoxidase activities were significantly higher than native myeloperoxidase activities (P = 0.020; P = 0.015; P = 0.004, respectively). A statistically significant difference in total histological score was detected in the J pouch + 5% dextran sulfate sodium (DSS) group, compared to the J pouch control and the J pouch + 5% DSS + PHGG groups (P < 0.01 and P < 0.01, respectively). There was a significant overgrowth of aerobes and anaerobes in the J pouch + 5% DSS group. This study demonstrated that rectal administration of PHGG attenuates the severity of pouchitis in a rat model. In conclusion, PHGG may be an additional therapeutic strategy for the treatment of pouchitis.

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Authors and Affiliations

  1. Department of Surgery, School of Medicine, Dokuz Eylul University, Izmir, 35340, Turkey

    Koray Atila, Cem Terzi & Aras Emre Canda

  2. Korutürk Mahallesi Kauçuk Sokak No:5 D:15, 35330, Balcova, Izmir, Turkey

    Koray Atila

  3. Department of Biochemistry, School of Medicine, Dokuz Eylul University, Izmir, 35340, Turkey

    Serpil Tanriverdi Akhisaroglu & Gulgun Oktay

  4. Department of Microbiology and Clinical Microbiology, School of Medicine, Dokuz Eylul University, Izmir, 35340, Turkey

    Hatice Sanli Avci & Zeynep Gulay

  5. Department of Pathology, School of Medicine, Dokuz Eylul University, Izmir, 35340, Turkey

    Sulen Sarioglu

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  1. Koray Atila
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Atila, K., Terzi, C., Canda, A.E. et al. Partially Hydrolyzed Guar Gum Attenuates the Severity of Pouchitis in a Rat Model of Ileal J Pouch-Anal Anastomosis. Dig Dis Sci 54, 522–529 (2009). https://doi.org/10.1007/s10620-008-0377-9

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  • DOI: https://doi.org/10.1007/s10620-008-0377-9

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