Twenty-Five Years of Research on Saccharomyces boulardii Trophic Effects: Updates and Perspectives

This is a preview of subscription content, access via your institution.

Fig. 1

References

  1. 1.

    Ducluzeau R, Bensaada M (1982) Comparative effect of a single or continuous administration of “Saccharomyces boulardii” on the establishment of various strains of “candida” in the digestive tract of gnotobiotic mice. Ann Microbiol (Paris) 133:491–501

    CAS  Google Scholar 

  2. 2.

    Surawicz CM, Elmer GW, Speelman P, McFarland LV, Chinn J, van Belle G (1989) Prevention of antibiotic-associated diarrhea by Saccharomyces boulardii: a prospective study. Gastroenterology 96:981–988

    PubMed  CAS  Google Scholar 

  3. 3.

    Szajewska H, Mrukowicz J (2005) Meta-analysis: non-pathogenic yeast Saccharomyces boulardii in the prevention of antibiotic-associated diarrhoea. Aliment Pharmacol Ther 22:365–372

    PubMed  Article  CAS  Google Scholar 

  4. 4.

    D’Souza AL, Rajkumar C, Cooke J, Bulpitt CJ (2002) Probiotics in prevention of antibiotic associated diarrhoea: meta-analysis. BMJ 324:1361

    PubMed  Article  Google Scholar 

  5. 5.

    Szajewska H, Skorka A, Dylag M (2007) Meta-analysis: Saccharomyces boulardii for treating acute diarrhoea in children. Aliment Pharmacol Ther 25:257–264

    PubMed  CAS  Google Scholar 

  6. 6.

    Kurugol Z, Koturoglu G (2005) Effects of Saccharomyces boulardii in children with acute diarrhoea. Acta Paediatr 94:44–47

    PubMed  Article  CAS  Google Scholar 

  7. 7.

    Mansour-Ghanaei F, Dehbashi N, Yazdanparast K, Shafaghi A (2003) Efficacy of Saccharomyces boulardii with antibiotics in acute amoebiasis. World J Gastroenterol 9:1832–1833

    PubMed  Google Scholar 

  8. 8.

    Besirbellioglu BA, Ulcay A, Can M, Erdem H, Tanyuksel M, Avci IY, Araz E, Pahsa A (2006) Saccharomyces boulardii and infection due to Giardia lamblia. Scand J Infect Dis 38:479–481

    PubMed  Article  Google Scholar 

  9. 9.

    Buts JP, Corthier G, Delmee M (1993) Saccharomyces boulardii for Clostridium difficile-associated enteropathies in infants. J Pediatr Gastroenterol Nutr 16:419–425

    PubMed  CAS  Google Scholar 

  10. 10.

    McFarland LV, Surawicz CM, Greenberg RN, Fekety R, Elmer GW, Moyer KA, Melcher SA, Bowen KE, Cox JL, Noorani Z et al (1994) A randomized placebo-controlled trial of Saccharomyces boulardii in combination with standard antibiotics for Clostridium difficile disease. JAMA 272:518

    Article  Google Scholar 

  11. 11.

    McFarland LV (2006) Meta-analysis of probiotics for the prevention of antibiotic associated diarrhea and the treatment of Clostridium difficile disease. Am J Gastroenterol 101:812–822

    PubMed  Article  Google Scholar 

  12. 12.

    Brar HS, Surawicz CM (2000) Pseudomembranous colitis: an update. Can J Gastroenterol 14:51–56

    PubMed  CAS  Google Scholar 

  13. 13.

    McFarland LV (2007) Meta-analysis of probiotics for the prevention of traveler’s diarrhea. Travel Med Infect Dis 5:97–105

    PubMed  Article  Google Scholar 

  14. 14.

    Kollaritsch H, Holst H, Grobara P, Wiedermann G (1993) Prevention of traveler’s diarrhea with Saccharomyces boulardii. Results of a placebo controlled double-blind study. Fortschr Med 111:152–156

    PubMed  CAS  Google Scholar 

  15. 15.

    Cremonini F, Di Caro S, Covino M, Armuzzi A, Gabrielli M, Santarelli L, Nista EC, Cammarota G, Gasbarrini G, Gasbarrini A (2002) Effect of different probiotic preparations on anti-helicobacter pylori therapy-related side effects: a parallel group, triple blind, placebo-controlled study. Am J Gastroenterol 97:2744–2749

    PubMed  Article  Google Scholar 

  16. 16.

    Duman DG, Bor S, Ozutemiz O, Sahin T, Oguz D, Istan F, Vural T, Sandkci M, Isksal F, Simsek I, Soyturk M, Arslan S, Sivri B, Soykan I, Temizkan A, Bessk F, Kaymakoglu S, Kalayc C (2005) Efficacy and safety of Saccharomyces boulardii in prevention of antibiotic-associated diarrhoea due to Helicobacterpylori eradication. Eur J Gastroenterol Hepatol 17:1357–1361

    PubMed  Article  Google Scholar 

  17. 17.

    Gaon D, Garcia H, Winter L, Rodriguez N, Quintas R, Gonzalez SN, Oliver G (2003) Effect of Lactobacillus strains and Saccharomyces boulardii on persistent diarrhea in children. Medicina (B Aires) 63:293–298

    Google Scholar 

  18. 18.

    Saint-Marc T, Rossello-Prats L, Touraine JL (1991) Efficacy of Saccharomyces boulardii in the treatment of diarrhea in AIDS. Ann Med Interne (Paris) 142:64–65

    CAS  Google Scholar 

  19. 19.

    Guslandi M, Mezzi G, Sorghi M, Testoni PA (2000) Saccharomyces boulardii in maintenance treatment of Crohn’s disease. Dig Dis Sci 45:1462–1464

    PubMed  Article  CAS  Google Scholar 

  20. 20.

    Guslandi M, Giollo P, Testoni PA (2003) A pilot trial of Saccharomyces boulardii in ulcerative colitis. Eur J Gastroenterol Hepatol 15:697–698

    PubMed  Article  Google Scholar 

  21. 21.

    Tempe JD, Steidel AL, Blehaut H, Hasselmann M, Lutun P, Maurier F (1983) Prevention of diarrhea administering Saccharomyces boulardii during continuous enteral feeding. Sem Hop 59:1409–1412

    PubMed  CAS  Google Scholar 

  22. 22.

    Bleichner G, Blehaut H, Mentec H, Moyse D (1997) Saccharomyces boulardii prevents diarrhea in critically ill tube-fed patients. A multicenter, randomized, double-blind placebo-controlled trial. Intensive Care Med 23:517–523

    PubMed  Article  CAS  Google Scholar 

  23. 23.

    Herek O (2002) Saccharomyces boulardii: a possible addition to the standard treatment and prophylaxis of enterocolitis in Hirschsprung’s disease? Pediatr Surg Int 18:567

    PubMed  Article  CAS  Google Scholar 

  24. 24.

    Szajewska H, Ruszczynski M, Radzikowski A (2007) Probiotics in the prevention of antibiotic-associated diarrhea in children: a meta-analysis of randomized controlled trials. J Pediatr 150:113–114

    Article  Google Scholar 

  25. 25.

    Johnston BC, Supina AL, Ospina M, Vohra S (2007) Probiotics for the prevention of pediatric antibiotic-associated diarrhea. Cochrane Database Syst Rev 18:CD004827

    Google Scholar 

  26. 26.

    Villarruel G, Rubio DM, Lopez F, Cintioni J, Gurevech R, Romero G, Vandenplas Y (2007) Saccharomyces boulardii in acute childhood diarrhoea: a randomized, placebo-controlled study. Acta Paediatr 96:538–541

    PubMed  Article  Google Scholar 

  27. 27.

    Costalos C, Skouteri V, Gounaris A, Sevastiadou S, Triandafilidou A, Ekonomidou C, Kontaxaki F, Petrochilou V (2003) Enteral feeding of premature infants with Saccharomyces boulardii. Early Hum Dev 74:89–96

    PubMed  Article  CAS  Google Scholar 

  28. 28.

    Linday LA (2001) Saccharomyces boulardii: potential adjunctive treatment for children with autism and diarrhea. J Child Neurol 16:387

    PubMed  Article  CAS  Google Scholar 

  29. 29.

    Maupas JL, Champemont P, Delforge M (1983) Treatment of irritable bowel syndrome with Saccharomyces boulardii: a double blind, placebo controlled study. Med Chir Dig 12:77–79

    Google Scholar 

  30. 30.

    Buts JP, Bernasconi P (2005) Saccharomyces boulardii: basic science and clinical applications in gastroenterology. Gastroenterol Clin North Am 34:515–532

    PubMed  Article  Google Scholar 

  31. 31.

    Buts JP, De Keyser N (2006) Effects of Saccharomyces boulardii on intestinal mucosa. Dig Dis Sci 51:1297–1508

    Article  Google Scholar 

  32. 32.

    Czerucka D, Piche T, Rampal P (2007) Review article: yeast as probiotics—Saccharomyces boulardii. Aliment Pharmacol Ther 26:767–778

    PubMed  CAS  Google Scholar 

  33. 33.

    Edwards-Ingram L, Gitsham P, Burton N, Warhurst G, Clarke I, Hoyle D, Oliver SG, Stateva L (2007) Genotypic and physiological characterization of Saccharomyces boulardii, the probiotic strain of Saccharomyces cerevisiae. Appl Environ Microbiol 73:2458–2467

    PubMed  Article  CAS  Google Scholar 

  34. 34.

    Malgoire JY, Bertout S, Renaud F, Bastide JM, Mallie M (2005) Typing of Saccharomyces cerevisiae clinical strains by using microsatellite sequence polymorphism. J Clin Microbiol 43:1133–1137

    PubMed  Article  CAS  Google Scholar 

  35. 35.

    Mitterdorfer G, Mayer HK, Kneifel W, Viernstein H (2002) Clustering of Saccharomyces boulardii strains within the species S. cerevisiae using molecular typing techniques. J Appl Microbiol 93:521–530

    PubMed  Article  CAS  Google Scholar 

  36. 36.

    van der Aa Kühle A, Jespersen L (2003) The taxonomic position of Saccharomyces boulardii as evaluated by sequence analysis of the D1/D2 domain of 26S rDNA, the ITS1-5.8S rDNA-ITS2 region and the mitochondrial cytochrome-c oxidase II gene. Syst Appl Microbiol 26:564–571

    PubMed  Article  Google Scholar 

  37. 37.

    Buts JP, Bernasconi P, Van Craynest MP, Maldague P, De Meyer R (1986) Response of human and rat small intestinal mucosa to oral administration of Saccharomyces boulardii. Pediatr Res 20:192–196

    PubMed  Article  CAS  Google Scholar 

  38. 38.

    Buts JP, Bernasconi P, Vaerman JP, Dive C (1990) Stimulation of secretory IgA and secretory component of immunoglobulins in small intestine of rats treated with Saccharomyces boulardii. Dig Dis Sci 35:251–256

    PubMed  Article  CAS  Google Scholar 

  39. 39.

    Buts JP, De Keyser N, Marandi S, Hermans D, Sokal EM, Chae YH, Lambotte L, Chanteux H, Tulkens PM (1999) Saccharomyces boulardii upgrades cellular adaptation after proximal enterectomy in rats. Gut 45:89–96

    PubMed  CAS  Article  Google Scholar 

  40. 40.

    Buts JP, De Keyser N, Stilmant C, Sokal E, Marandi S (2002) Related articles, links Saccharomyces boulardii enhances N-terminal peptide hydrolysis in suckling rat small intestine by endoluminal release of a zinc-binding metalloprotease. Pediatr Res 51:528–534

    PubMed  Article  CAS  Google Scholar 

  41. 41.

    Buts JP, Dekeyser N, Stilmant C, Delem E, Smets F, Sokal E (2006) Saccharomyces boulardii produces in rat small intestine a novel protein phosphatase that inhibits Escherichia coli endotoxin by dephosphorylation. Pediatr Res 60:24–29

    PubMed  Article  CAS  Google Scholar 

  42. 42.

    Buts JP, De Keyser N, De Raedemaeker L (1994) Saccharomyces boulardii enhances rat intestinal enzyme expression by endoluminal release of polyamines. Pediatr Res 36:522–527

    PubMed  Article  CAS  Google Scholar 

  43. 43.

    Buts JP, De Keyser N, Kolanowski J, Sokal E, Van Hoof F (1993) Maturation of villus and crypt cell functions in rat small intestine. Role of dietary polyamines. Dig Dis Sci 38:1091–1098

    PubMed  Article  CAS  Google Scholar 

  44. 44.

    Wery I, Kaouass M, Deloyer P, Buts JP, Barbason H, Dandrifosse G (1996) Exogenous spermine induces maturation of the liver in suckling rats. Hepatology 24:1206–1210

    PubMed  CAS  Google Scholar 

  45. 45.

    Marandi S, De Keyser N, Saliez A, Maernoudt AS, Sokal EM, Stilmant C, Rider MH, Buts JP (2001) Insulin signal transduction in rat small intestine: role of MAP kinases in expression of mucosal hydrolases. Am J Physiol Gastrointest Liver Physiol 280:G229–240

    PubMed  CAS  Google Scholar 

  46. 46.

    Marandi S, De Keyser N, Stilmant C, Saliez A, Sokal EM, Guiot Y, Buts JP (2002) Ontogeny of MAP kinases in rat small intestine: premature stimulation by insulin of BBM hydrolases is regulated by ERKs but not by p-38 MAP kinase. Pediatr Res 52:180–188

    PubMed  CAS  Google Scholar 

  47. 47.

    Kolch W (2005) Coordinating ERK/MAPK signalling through scaffolds and inhibitors. Nat Rev Mol Cell Biol 6:827–837

    PubMed  Article  CAS  Google Scholar 

  48. 48.

    Giancotti FG, Ruoslahti E (1999) Integrin signaling. Science 285:1028–1032

    PubMed  Article  CAS  Google Scholar 

  49. 49.

    Dikic I, Blaukat A (1999) Protein tyrosine kinase-mediated pathways in G protein-coupled receptor signaling. Cell Biochem Biophys 30:369–387

    PubMed  Article  CAS  Google Scholar 

Download references

Acknowledgments

The authors would like to thank Mr B. Hublot for helpful comments on the manuscript.

Author information

Affiliations

Authors

Corresponding author

Correspondence to Jean-Paul Buts.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Buts, JP. Twenty-Five Years of Research on Saccharomyces boulardii Trophic Effects: Updates and Perspectives. Dig Dis Sci 54, 15–18 (2009). https://doi.org/10.1007/s10620-008-0322-y

Download citation

Keywords

  • Lactase
  • Trophic Effect
  • Saccharomyces Boulardii
  • Acute Infectious Diarrhea
  • Biotherapeutic Agent