Abstract
Capsule endoscopy (CE) has proved to be the preferred modality for mucosal pathologies of the small bowel. We evaluated the capability of CE for detecting small bowel ulcers and the contribution of CE in establishing the diagnosis. From a total of 66 patients who had undergone normal upper and lower endoscopy and small bowel follow-through, CE revealed previously undiagnosed ulcer(s) in the small intestines of 22 patients. Final diagnoses of the ulcers of these 22 patients were Crohn’s disease (n = 9), Behçet’s disease (n = 2), nonspecific jejunoileitis (n = 2), vasculitis (n = 1), gastrointestinal stromal tumor (n = 1), adenocarcinoma (n = 1), lymphoma (n = 1), multiple myeloma (n = 1), Meckel’s diverticulum (n = 1) and unknown (n = 3). Capsule endoscopy was extremely useful in establishing the diagnosis. In this study, proximal, distal and diffuse small bowel ulcers were determined at rates of 27.3, 59.0 and 13.7%, respectively. Capsule endoscopy facilitated the detection and assessment of ulcerated mucosal lesions located in the small bowel.
Similar content being viewed by others
References
Proctor DD, Panzini LA (2002) Isolated and diffuse ulcers of the small intestine. In: Feldman M, Friedman LS, Sleisenger MH (eds) Sleisenger and Fordran’s gastrointestinal and liver disease, 7th edn. Saunders, Philadelphia, pp 2081–2088
Eliakim AR (2006) Video capsule endoscopy of the small bowel (PillCam SB). Curr Opin Gastroenterol 22:124–127. doi:10.1097/01.mog.0000203866.25384.be
Ghosh S, Watts D, Kinnear M (2002) Management of gastrointestinal haemorrhage. Postgrad Med J 78:4–14. doi:10.1136/pmj.78.915.4
Yamamoto H, Kita H, Sunada K et al (2004) Clinical outcomes of double-balloon endoscopy for the diagnosis and treatment of small-intestinal diseases. Clin Gastroenterol Hepatol 2:1010–1016. doi:10.1016/S1542-3565(04)00453-7
Tang SJ, Zanati S, Dubcenco E et al (2003) Capsule endoscopy regional transit abnormality: a sign of underlying small bowel pathology. Gastrointest Endosc 58:598–602
Ell C, Remke S, May A et al (2002) The first prospective controlled trial comparing wireless capsule endoscopy with push enteroscopy in chronic gastrointestinal bleeding. Endoscopy 34:685–689. doi:10.1055/s-2002-33446
Mata A, Bordas JM, Feu F (2004) Wireless capsule endoscopy in patients with obscure gastrointestinal bleeding: a comparative study with push enteroscopy. Aliment Pharmacol Ther 20:189–194. doi:10.1111/j.1365-2036.2004.02067.x
Mylonaki M, Fritscher-Ravens A, Swain P (2003) Wireless capsule endoscopy: a comparison with push enteroscopy in patients with gastroscopy and colonoscopy negative gastrointestinal bleeding. Gut 52:1122–1126. doi:10.1136/gut.52.8.1122
Lim RM, O’Loughlin CJ, Barkin JS (2002) Comparison of wireless capsule endoscopy (M2A) with push enteroscopy in the evaluation of obscure gastrointestinal bleeding. Am J Gastroenterol 97:S-31
Adler DG, Knipschield M, Gostout C (2004) A prospective comparison of capsule endoscopy and push enteroscopy in patients with GI bleeding of obscure origin. Gastrointest Endosc 59:492–498. doi:10.1016/S0016-5107(03)02862-1
Saurin JC, Delvaux M, Gaudin JL et al (2003) Diagnostic value of endoscopic capsule in patients with obscure digestive bleeding: blinded comparison with video push enteroscopy. Endoscopy 35:576–584. doi:10.1055/s-2003-38767
Hartmann D, Schilling D, Bolz G et al (2003) Capsule endoscopy versus push enteroscopy in patients with occult gastrointestinal bleeding. Z Gastroenterol 41:377–382. doi:10.1055/s-2003-37313
Van Gossum A, Hittelet A, Schmit A et al (2003) A prospective comparative study of push and wireless-capsule enteroscopy in patients with obscure digestive bleeding. Acta Gastroenterol Belg 66:199–205.
Ge ZZ, Hu YB, Xiao SD (2004) Capsule endoscopy and push enteroscopy in the diagnosis of obscure gastrointestinal bleeding. Chin Med J (Engl) 117:1045–1049
Liangpunsakul S, Maglinte DD, Rex DK (2004) Comparison of wireless capsule endoscopy and conventional radiologic methods in the diagnosis of small bowel disease. Gastrointest Endosc Clin N Am 14:43–50. doi:10.1016/j.giec.2003.10.004
Costamagna G, Shah SK, Riccioni ME et al (2002) A prospective trial comparing small bowel radiographs and video capsule endoscopy for suspected small bowel disease. Gastroenterology 123:999–1005. doi:10.1053/gast.2002.35988
Liangpunsakul S, Chadalawada V, Rex D et al (2003) Wireless capsule endoscopy detects small bowel ulcers in patients with normal results from state of the art enteroclysis. Am J Gastroenterol 98:1295–1298. doi:10.1111/j.1572-0241.2003.07471.x
Hara AK, Leighton JA, Sharma VK et al (2005) Imaging of small bowel disease: comparison of capsule endoscopy, standard endoscopy, barium examination, and CT. Radiographics 25:697–718. doi:10.1148/rg.253045134
Voderholzer WA, Beinhoelzl J, Rogalla P et al (2005) Small bowel involvement in Crohn’s disease: a prospective comparison of wireless capsule endoscopy and computed tomography enteroclysis. Gut 54:369–373. doi:10.1136/gut.2004.040055
Remedios ML, Appleyard M (2005) Capsule endoscopy: current indications and future prospects. Intern Med J 35:234–239. doi:10.1111/j.1445-5994.2005.00808.x
Triester SL, Leighton JA, Leontiadis GI et al (2006) A meta-analysis of the yield of capsule endoscopy compared to other diagnostic modalities in patients with non-stricturing small bowel Crohn’s disease. Am J Gastroenterol 101:954–964. doi:10.1111/j.1572-0241.2006.00506.x
American Society for Gastrointestinal Endoscopy (2002) Wireless capsule endoscopy. Gastrointest Endosc 56:621–624. doi:10.1016/S0016-5107(02)70106-5
Delvaux M (2006) Capsule endoscopy in 2005: facts and perspectives. Best Pract Res Clin Gastroenterol 20:23–39. doi:10.1016/j.bpg.2005.08.002
Ersoy O, Sivri B, Arslan S et al (2006) How much helpful is the capsule endoscopy for the diagnosis of small bowel lesions? World J Gastroenterol 28:3906–3910
Swain P (2005) Wireless capsule endoscopy and Crohn’s disease. Gut 54:323–326. doi:10.1136/gut.2004.047282
Kasahara Y, Tanaka S, Nihino M et al (1981) Intestinal involvement in Behcet’s disease: review of 136 surgical cases in the Japanese literature. Dis Colon Rectum 24:103–106. doi:10.1007/BF02604297
Smith JA, Siddiqui D (2002) Intestinal Behcet’s disease presenting as a massive acute lower gastrointestinal bleed. Dig Dis Sci 47:517–521. doi:10.1023/A:1017999515606
Hara AK, Leighton JA, Sharma VK et al (2004) Small bowel: preliminary comparison of capsule endoscopy with barium study and CT. Radiology 230:260–265. doi:10.1148/radiol.2301021535
Berner JS, Mauer K, Lewis BS (1994) Push and sonde enteroscopy for the diagnosis of obscure gastrointestinal bleeding. Am J Gastroenterol 89:2139–2142
Lewis B, Eisen G, Friedman S (2005) A pooled analysis to evaluate results of capsule endoscopy trials. Endoscopy 37:960–965. doi:10.1055/s-2005-870353
Green PH, Jabri B (2003) Coeliac disease. Lancet 362:383–391.doi:10.1016/S0140-6736(03)14027-5
Culliford A, Daly J, Diamond B et al (2005) The value of wireless capsule endoscopy in patients with complicated celiac disease. Gastrointest Endosc 62:55–61. doi:10.1016/S0016-5107(05)01566-X
Muller-Ladner U (2001) Vasculitides of the gastrointestinal tract. Best Pract Res Clin Gastroenterol 15:59–82. doi:10.1053/bega.2000.0156
Venizelos I, Theodoridou S, Vakalopoulou S et al (2004) Acute large bowel pseudo-obstruction due to multiple myeloma. Leuk Lymphoma 45:1943–1945. doi:10.1080/10428190410001697322
Yamamoto T, Maeda N, Kawasaki H (1995) Hepatic failure in a case of multiple myeloma-associated amyloidosis (k-AL). J Gastroenterol 30:393–397. doi:10.1007/BF02347517
Cooper MM (1988) Metastatic calcification: an unusual cause of lower intestinal hemorrhage. N Y State J Med 88:389–390
Katz JA, Metz DC, Faigel DO (1994) Gastrointestinal bleeding from a gastric plasmacytoma. Am J Gastroenterol 89:642–643
Chang SS, Lu CL, Tsay SH et al (2001) Amyloidosis-induced gastrointestinal bleeding in a patient with multiple myeloma. J Clin Gastroenterol 32:161–163. doi:10.1097/00004836-200102000-00015
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Ersoy, O., Harmanci, O., Aydinli, M. et al. Capability of Capsule Endoscopy in Detecting Small Bowel Ulcers. Dig Dis Sci 54, 136–141 (2009). https://doi.org/10.1007/s10620-008-0320-0
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10620-008-0320-0