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Homozygous 825T Allele of the GNB3 Protein Influences the Susceptibility of Japanese to Dyspepsia

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Abstract

The role of genetics in the susceptibility to functional dyspepsia (FD) is not well established. Recently, two different associations were reported between FD and G-protein beta3 (GNB3) subunit gene polymorphism. We aim to clarify the association between GNB3 protein C825T polymorphism and dyspepsia in the Japanese population. Eight-nine dyspeptics and 94 nondyspeptic subjects enrolled in this study. All subjects underwent gastroscopy and patients with significant upper gastrointestinal findings were excluded. Other diseases were also excluded by face-to-face history and physical examination. GNB3 protein C825T polymorphisms were determined by polymerase chain reaction-restriction fragment-length polymorphism. H. pylori infection status was examined by histology or antibody against H. pylori. Nonsignificant correlation was found between GNB3 protein homozygous 825T and unexplained dyspepsia (OR = 1.65, 95% CI: 0.87–3.13). However, among H. pylori-negative subjects, homozygous GNB3 protein 825T significantly increased the risk of dyspepsia (16.7% versus 40.5%; CC versus TT; OR = 5.10, 95% CI: 1.21–21.43, CC versus others; OR = 3.40, 95% CI: 1.16–9.93, respectively). This significant association remained after logistic regression analysis with adjustment for sex and age (CC versus TT; OR = 5.73, 95% CI: 1.27–25.82, CC versus others; OR = 3.08, 95% CI: 1.02–9.25). No significant correlation was found between GNB3 polymorphism and any dyspeptic symptoms. Our data suggest that the homozygous 825T allele of GNB3 protein is associated with dyspepsia in the H. pylori-negative Japanese population. The role of genetics in the development of dyspepsia needs further evaluation.

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Authors and Affiliations

  1. Department of Gastroenterology, Fujita Health University School of Medicine, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi, 470-1192, Japan

    Tomomitsu Tahara, Tomiyasu Arisawa, Tomoyuki Shibata, Fangyu Wang, Masakatsu Nakamura, Mikijyu Sakata & Ichiro Hirata

  2. Fujita Health University, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi, 470-1192, Japan

    Hiroshi Nakano

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  1. Tomomitsu Tahara
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  2. Tomiyasu Arisawa
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  3. Tomoyuki Shibata
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  4. Fangyu Wang
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  5. Masakatsu Nakamura
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  6. Mikijyu Sakata
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  7. Ichiro Hirata
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  8. Hiroshi Nakano
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Correspondence to Tomomitsu Tahara.

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Tahara, T., Arisawa, T., Shibata, T. et al. Homozygous 825T Allele of the GNB3 Protein Influences the Susceptibility of Japanese to Dyspepsia. Dig Dis Sci 53, 642–646 (2008). https://doi.org/10.1007/s10620-007-9923-0

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  • DOI: https://doi.org/10.1007/s10620-007-9923-0

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