Abstract
Cholecystectomy has been identified as a risk factor for colorectal cancer, yet little attention has been given to the relationship between cholecystectomy and colorectal adenomas. Utilizing data collected in two large cross-sectional studies of colorectal adenoma risk factors, we examined the association between cholecystectomy and colorectal adenomas. In the adjusted logistic regression model, both men and women showed no effect of cholecystectomy on risk of colorectal adenomas (men: OR 0.67 [95% CI 0.30–1.47]; women: OR 1.46 [95% CI 0.92–2.29]). No effect was seen when examining the time since cholecystectomy for men. There was a slight association found for women who had a cholecystectomy less than 10 years prior (OR 2.02 [95% CI 1.06–3.87]) but no association was seen in women with cholecystectomy at least 10 years prior (OR 1.14 [95% CI 0.62–2.09]). Thus, we conclude that, although cholecystectomy is a risk factor for colorectal cancer, cholecystectomy is not a risk factor for colorectal adenomas.
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Acknowledgements
We would like to thank Dr. Alexandra C. Frost for providing invaluable background information on DHS III and DHS IV and Dr. David Ransohoff for his reviews of initial drafts of this manuscript. This work was supported in part by the NIH grants T32 DK07634, R01 DK 44684, and P30 DK34987.
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Vinikoor, L.C., Galanko, J.A. & Sandler, R.S. Cholecystectomy and the Risk of Colorectal Adenomas. Dig Dis Sci 53, 730–735 (2008). https://doi.org/10.1007/s10620-007-9912-3
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DOI: https://doi.org/10.1007/s10620-007-9912-3