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13C-Urea Breath Test Values and Helicobacter pylori Eradication

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Abstract

Delta over baseline (DOB) values of 13C-urea breath test (UBT) have been shown to be predictive of H. pylori eradication following therapy. This was a post hoc analysis of a large, double-blind, randomized trial. Consecutive patients with a positive UBT underwent upper endoscopy. H. pylori strains were tested for clarithromycin resistance. All patients received an eradication therapy with either a standard 10-day triple therapy or a 10-day sequential regimen. The infection was considered cured when two consecutive UBTs were negative. Basal DOB values were categorized as low (<16), intermediate (16–35), or high (>35). A total of 282 patients were selected. Eradication rates did not differ between patients with high and low DOB values. No significant difference in DOB values emerged between patients infected with clarithromycin-susceptible and clarithromycin-resistant strains. Under multivariate analysis, DOB values did not influence the bacterial eradication, which was significantly affected only by the presence of clarithromycin resistance. This large analysis failed to demonstrate a role for DOB value in H. pylori eradication with either a 10-day triple or sequential therapy.

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Authors and Affiliations

  1. Gastroenterology and Digestive Endoscopy, Nuovo Regina Margherita Hospital, Via E. Morosini, 30, Rome, 00153, Italy

    Angelo Zullo, Cesare Hassan & Sergio Morini

  2. Department of Internal Medicine and Gastroenterology, University of Bologna, Bologna, Italy

    Federico Perna, Andrea Tampieri & Dino Vaira

  3. Gastroenterology Unit, University of Brescia, Brescia, Italy

    Chiara Ricci

  4. Gastroenterology Unit, “Riuniti” Hospital, Foggia, Italy

    Vincenzo De Francesco

Authors
  1. Angelo Zullo
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  2. Federico Perna
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  3. Chiara Ricci
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  4. Cesare Hassan
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  5. Andrea Tampieri
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  6. Vincenzo De Francesco
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  7. Sergio Morini
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  8. Dino Vaira
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Correspondence to Angelo Zullo.

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Zullo, A., Perna, F., Ricci, C. et al. 13C-Urea Breath Test Values and Helicobacter pylori Eradication. Dig Dis Sci 53, 370–374 (2008). https://doi.org/10.1007/s10620-007-9893-2

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  • DOI: https://doi.org/10.1007/s10620-007-9893-2

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