Skip to main content
SpringerLink
Log in

Prevalence of Macrocreatinkinase Type 1 in Patients with Inflammatory Bowel Disease

  • Original Paper
  • Published:
Digestive Diseases and Sciences Aims and scope Submit manuscript

Abstract

Macro-creatine-kinases are isoenzymes of creatinine-kinases (CK). They have been classified in two types: type 1 (CK bound to an immunoglobulin) and type 2 (an oligomeric mitochondrial CK). CK type 1 has been found in patients with ulcerative colitis (UC) but not in Crohn’s disease (CD). However, there are no studies evaluating macro-creatinkinase prevalence in inflammatory bowel disease (IBD). We included 159 consecutive patients (72 UC, 85 CD; 2 indeterminate colitis). Creatin-kinase total activity and isoenzymes activities were determined. Twelve (16.7%) patients with UC and one of the two patients with indeterminate colitis had serum macro-creatinkinase type 1 while no CD patients displayed this macromolecule (P < 0,001). Sensitivity, specificity, positive and negative predictive value, and positive and negative likelihood ratio were calculated for ulcerative colitis versus Crohn’s disease diagnosis, being 16.7, 98.9, 92.3, 59, 14.5, and 0.84% respectively. There was no correlation with age, gender, time from diagnosis, associated diseases, concomitant medication or disease activity. In conclusion our data suggests that the presence of macro-CK in IBD favors the diagnosis of ulcerative colitis. Further studies are necessary to understand the significance of this finding in a subset of patients with IBD.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Similar content being viewed by others

References

  1. Lang H, Wurzburg U (1982) Creatine kinase, an enzyme of many forms. Clin Chem 28(7):1439–1447

    PubMed  CAS  Google Scholar 

  2. Mifflin TE, Bruns DE, Wrotnoski U, MacMillan RH, Stallings RG, Felder RA, Herold DA (1985) University of Virginia case conference. Macroamylase, macro creatine kinase, and other macroenzymes. Clin Chem 31(10):1743–1748

    PubMed  CAS  Google Scholar 

  3. Laureys M, Sion JP, Slabbynck H, Steenssens L, Cobbaert C, Derde MP, Gorus FK (1991) Macromolecular creatine kinase type 1: a serum marker associated with disease. Clin Chem 37(3):430–434

    PubMed  CAS  Google Scholar 

  4. Lee KN, Csako G, Bernhardt P, Elin RJ (1994) Relevance of macro creatine kinase type 1 and type 2 isoenzymes to laboratory and clinical data. Clin Chem 40(7 Pt 1):1278–1283

    PubMed  CAS  Google Scholar 

  5. Stein W, Bohner J, Renn W, Maulbetsch R (1985) Macro creatine kinase type 2: results of a prospective study in hospitalized patients. Clin Chem 31(12):1959–1964

    PubMed  CAS  Google Scholar 

  6. Remaley AT, Wilding P (1989) Macroenzymes: biochemical characterization, clinical significance, and laboratory detection. Clin Chem 35(12):2261–2270

    PubMed  CAS  Google Scholar 

  7. Tozawa T (1989) Enzyme-linked immunoglobulins and their clinical significance. Electrophoresis 10(8–9):640–644

    Article  PubMed  CAS  Google Scholar 

  8. Perez Calle JL, Marcos IM, Carneros JA, Barrio J, Trascasa C, Munoz E, Mancheno E, Gonzalez Lara V (2001) [Macromolecular creatinine kinase in patients diagnosed with ulcerative colitis]. Gastroenterol Hepatol 24(1):16–19

    PubMed  CAS  Google Scholar 

  9. Szasz G, Gerhardt W, Gruber W, Bernt E (1976) Creatine kinase in serum: 2. Interference of adenylate kinase with the assay. Clin Chem 22(11):1806–1811

    PubMed  CAS  Google Scholar 

  10. Szasz G, Gruber W, Bernt E (1976) Creatine kinase in serum: 1. Determination of optimum reaction conditions. Clin Chem 22(5):650–656

    PubMed  CAS  Google Scholar 

  11. Wurzburg U, Hennrich N, Lang H, Prellwitz W, Neumeier D, Knedel M (1976) [Determination of creatine kinase-MB in serum using inhibiting antibodies (author’s transl)]. Klin Wochenschr 54(8):357–360

    Article  PubMed  CAS  Google Scholar 

  12. Rosa-Jimenez F, Gasso de Campos M, Camacho Reina MV, Vazquez de Castroviejo E, Hernandez Burruezo JJ, Pousibet Sanfeliu H (1997) [Macro creatine kinase type 1 as a cause of increase of CF-MB isoenzyme. Apropos of 7 cases]. Rev Esp Cardiol 50(3):166–172

    PubMed  CAS  Google Scholar 

  13. Stein W, Bohner J (1985) Need the small laboratory still use the plasma creatine kinase/aspartate aminotransferase ratio? Clin Chem 31(11):1910

    PubMed  CAS  Google Scholar 

  14. Keren DF, Goeken JA (1997) Autoimmune reactivity in inflammatory bowel disease. Clin Lab Med 7(3):465–481

    Google Scholar 

  15. Gisbert JP, Gomollon F, Mate J, Pajares JM (2003) [The role of anti-neutrophil cytoplasmic antibodies (ANCA) and anti-Saccharomyces cerevisiae antibodies (ASCA) in inflammatory bowel disease]. Gastroenterol Hepatol 26(5):312–324

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Gastroenterology Unit, Fundación Hospital Alcorcon, Alcorcon, Spain

    J. L. Perez-Calle, P. Lopez-Serrano & C. Fernandez-Rodriguez

  2. C/ Eduardo Morales 37 1 A, Madrid, 28025, Spain

    J. L. Perez-Calle

  3. Hospital General Universitario Gregorio Maranon, Madrid, Spain

    I. Marin-Jimenez

  4. Hospital Universitario de la Princesa, Madrid, Spain

    J. P. Gisbert

  5. Department of Gastroenterology, VU University Medical Centre, Amsterdam, The Netherlands

    A. S. Pena

Authors
  1. J. L. Perez-Calle
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. I. Marin-Jimenez
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. P. Lopez-Serrano
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. J. P. Gisbert
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. A. S. Pena
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. C. Fernandez-Rodriguez
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to J. L. Perez-Calle.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Perez-Calle, J.L., Marin-Jimenez, I., Lopez-Serrano, P. et al. Prevalence of Macrocreatinkinase Type 1 in Patients with Inflammatory Bowel Disease. Dig Dis Sci 53, 486–489 (2008). https://doi.org/10.1007/s10620-007-9888-z

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10620-007-9888-z

Keywords

Search

Navigation