The purpose of this study was to investigate and compare the specificity, sensitivity, and area under curve (AUC) of the lactulose/mannitol ratio, lactulose/creatinine ratio, and lactulose recovery and their diagnostic value for intestinal permeability assessment within the absorption lactulose/mannitol (L/M) test. Results The value of the lactulose/mannitol ratio, lactulose/creatinine ratio, and the percentage of lactulose recovery in Crohn’s disease (0.0763 ± 0.0369; 99.62 ± 67.87; 1.0478 ± 0.6148) and in liver cirrhosis (0.0517 ± 0.0365; 54.65 ± 53.26; 0.838 ± 0.929) were significantly different from the values measured in the control group (0.0123 ± 0.0081; 10.95 ± 7.07; 0.2438 ± 0.1568), P < 0.0001–0.002). In Crohn’s disease, specificity, sensitivity, and AUC were 100%, 89.5%, and 0.987, respectively, of the lactulose/mannitol ratio at a cut-off level of 0.022. In liver cirrhosis, the test characteristics were 88.5%, 84.2%, and 0.910 at a cut-off level of 0.018. Conclusion The lactulose/mannitol ratio was evaluated to have the highest diagnostic value to assess intestinal permeability.
Lactulose Mannitol Intestinal permeability Sensitivity Specificity Area under curve
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This work was supported by the Grant Agency of the Health Ministerium, Czech Republic NR9084-3.
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