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Prevalence of Peptic Ulcer in Dyspeptic Patients and the Influence of Age, Sex, and Helicobacter pylori Infection

Digestive Diseases and Sciences volume 53, pages 2650–2656 (2008)Cite this article

Abstract

We investigated the prevalence of peptic ulcer in dyspeptic patients in China to analyze the influence of age, sex, and Helicobacter pylori (H. pylori) infection. The results showed that the prevalence of gastric and duodenal ulcer increased with age. In patients under 60 years old, the prevalence of duodenal and gastric ulcers in females was markedly lower than that in males, especially the prevalence of duodenal ulcer. The prevalence of duodenal ulcer and gastric ulcer in H. pylori-infected patients was markedly higher than in patients without H. pylori infection. In the patients under 60 years old, sex differences were still seen in both H. pylori-positive and H. pylori-negative patients. The prevalence of gastric and duodenal ulcers was markedly increased with age in both H. pylori-positive and H. pylori-negative patients. Multivariate logistic regression analysis showed that age, male sex, and H. pylori infection were three independent risk factors for gastric and duodenal ulcers.

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Abbreviations

GU:

Gastric ulcer

DU:

Duodenal ulcer

HP:

H. pylori

References

  1. Bernersen B, Johnsen R, Straume B et al (1990) Towards a true prevalence of peptic ulcer: the Sorreisa gastrointestinal disorder study. Gut 31:989–992

    PubMed  Article  CAS  Google Scholar 

  2. Kurata J, Nagawa AN, Abbey DE et al (1992) A prospective study of risk for peptic ulcer disease in Seventh-Day Adventists. Gastroenterology 102:902–909

    PubMed  CAS  Google Scholar 

  3. Rosenstock SJ, Jorqensen T (1995) Prevalence and incidence of peptic ulcer disease in a Danish county – a prospective cohort study. Gut 36:819–824

    PubMed  Article  CAS  Google Scholar 

  4. Everhart JE, Byrd-Holt D, Sonnenberg A (1998) Incidence and risk factors for self-reported peptic ulcer disease in the United States. Am J Epidemiol 147:529–536

    PubMed  CAS  Google Scholar 

  5. Kang JY, Elders A, Majeed A et al (2006) Recent trends in hospital admission and mortality rates for peptic ulcer in Scotland 1982–2002. Aliment Pharmacol Ther 24:65–79

    PubMed  Article  CAS  Google Scholar 

  6. Nervi G, Liatopoulou S, Giovanni L et al (2006) Does Helicobacter pylori infection eradication modify peptic ulcer prevalence? A 10 years’ endoscopical survey. World J Gastroenterol 12:2398–2401

    PubMed  Google Scholar 

  7. Chen TS, Tsay SH, Chang FY et al (1994) Effect of eradication of Helicobacter pylori on serum pepsinogen I, gastrin, and insulin in duodenal ulcer patients: a 12-month follow-up study. Am J Gastroenterol 89:1511–1514

    PubMed  CAS  Google Scholar 

  8. Kusters JG, van Vliet AH, Kuipers EJ (2006) Pathogenesis of Helicobacter pylori infection. Clin Microbiol Rev 19:449–490

    PubMed  Article  CAS  Google Scholar 

  9. Lam SK, Hui WM, Ching CK (1994) Peptic ulcer disease: epidemiology, pathogenesis and etiology. In: Haubrich WS, Schaffner F, Berk JE (eds) Bockus gastroenterology, 5th edn. WB Saunders, Philadelphia, pp 700–748

    Google Scholar 

  10. Schabowski J, Pitera J (2004) Peptic ulcer among rural population in a selected region of south-eastern Poland. Ann Agric Environ Med 11:323–327

    PubMed  Google Scholar 

  11. Dong WG, Cheng CS, Liu SP et al (2004) Epidemiology of peptic ulcer disease in Wuhan area of China from 1997 to 2002. World J Gastroenterol 10:3377–3379

    PubMed  Google Scholar 

  12. Singh V, Trikha B, Nain CK et al (2002) Epidemiology of Helicobacter pylori and peptic ulcer in India. J Gastroenterol Hepatol 17:659–665

    PubMed  Article  Google Scholar 

  13. Hsu PI, Lai KH, Lo GH et al (2002) Risk factors for ulcer development in patients with non-ulcer dyspepsia: a prospective two year follow up study of 209 patients. Gut 51:15–20

    PubMed  Article  Google Scholar 

  14. Tytgat GN (1995) No Helicobacter pylori, no Helicobacter pylori-associated peptic ulcer disease. Aliment Pharmacol Ther 9(Suppl 1):39–42

    PubMed  Google Scholar 

  15. Kuipers EJ, Thijs JC, Festen HP (1995) The prevelence of Helicobacter pylori in peptic ulcer disease. Aliment Pharmacol Ther 9(Suppl 2):59–69

    PubMed  Google Scholar 

  16. Chan FK, Leung WK (2002) Peptic ulcer disease. Lancet 360:933–941

    PubMed  Article  Google Scholar 

  17. van der Hulst RW, Rauws EA, Koycu B et al (1997) Prevention of ulcer recurrence after eradication of H. pylori: a prospective long-term follow-up study. Gastroenterology 113:1082–1086

    PubMed  Article  Google Scholar 

  18. Treiber G, Lambert JR (1998) The impact of H. pylori eradication on peptic ulcer healing. Am J Gastroenterol 93:1080–1084

    PubMed  Article  CAS  Google Scholar 

  19. Pulvertaft CN (1959) Peptic ulcer in town and country. Br J Prev Soc Med 13:131

    PubMed  CAS  Google Scholar 

  20. Lindstrom CG (1978) Gastric and duodenal peptic ulcer disease in a well-defined population. A prospective necropsy study in Malmo, Sweden. Scand J Gastroenterol 13:139–143

    PubMed  CAS  Article  Google Scholar 

  21. Soll AH, Weinstein WM, Kurata JH et al (1991) Nonsteroidal anti-inflammatory drugs and peptic ulcer disease. Ann Intern Med 114:307–319

    PubMed  CAS  Google Scholar 

  22. Goto H, Sugiyama S, Ohara A et al (1992) Age-associated decrease in prostaglandin contents in human gastric mucosa. Biochem Biophy Res Commun 186:1443–1448

    Article  CAS  Google Scholar 

  23. Cryer B, Redfern JS, Goldschmiedt M et al (1992) Effect of age on gastric and duodenal mucosal prostaglandin concentrations in humans. Gastroenterology 102:1118–1123

    PubMed  CAS  Google Scholar 

  24. Feldman M, Cryer B (1998) Effects of normal aging on gastric nonparietal fluid and electrolyte secretion in humans. Gerontology 44:222–227

    PubMed  Article  CAS  Google Scholar 

  25. Hawkey CJ, Wilson I, Nasdal J et al (2002) Influence of sex and Helicobacter pylori on development and healing of gastrointestinal lesions in non-steroidal anti-inflammatory drug users. Gut 51:344–350

    PubMed  Article  CAS  Google Scholar 

  26. Vakiland BJ, Mulekar AM (1965) Studies with the maximal histamine test. Gut 6:364–371

    PubMed  Article  CAS  Google Scholar 

  27. Baron JH (1969) Lean body mass, gastric acid and peptic ulcer. Gut 10:637–642

    PubMed  Article  CAS  Google Scholar 

  28. Taylor IL (1988) Duodenal ulcer disease. In: Gitnick G, Hollander D, Kaplowitz et al (eds) Principles and practice of gastroenterology and hepatology. Elsevier, New York, pp 175–190

  29. Korman MG, Hansky J, Eaves ER et al (1983) Influence of cigarette smoking on healing and relapse in duodenal ulcer disease. Gastroenterology 85:871–874

    PubMed  CAS  Google Scholar 

  30. Chen TS, Chang FY, Lee SD (1999) Smoking and male gender rather than CagA protein are associated with increased risk for duodenal ulcer in Helicobacter pylori-infected patients in Taiwan. Dig Dis Sci 44:2076–2080

    PubMed  Article  CAS  Google Scholar 

  31. Oluwole FS, Bolarinwa AF (1990) Effects of gonadectomy on indomethacin-induced ulceration and peptic activity in rats. Afr J Med Sci 19:139–143

    CAS  Google Scholar 

  32. Aguwa CN (1984) Effects of exogenous administration of female sex hormones on gastric secretion and ulcer formation in the rat. Eur J Pharmacol 104:79–84

    PubMed  Article  CAS  Google Scholar 

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Acknowledgement

This study was supported by a Grant from the Affiliated Hospital, Zunyi Medical College to Pro. Tuo.

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Affiliations

  1. Department of Gastroenterology, Affiliated Hospital, Zunyi Medical College, Zunyi, 563003, China

    Hui-Chao Wu, Bi-Guang Tuo, Yuan Gao & Kui Zhao

  2. Department of Gastroenterology, Zunyi Hospital, Zunyi, 563003, China

    Wei-Min Wu & Qing-Qing Xu

Authors
  1. Hui-Chao Wu
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  2. Bi-Guang Tuo
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  3. Wei-Min Wu
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  4. Yuan Gao
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  5. Qing-Qing Xu
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  6. Kui Zhao
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Correspondence to Bi-Guang Tuo.

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Wu, HC., Tuo, BG., Wu, WM. et al. Prevalence of Peptic Ulcer in Dyspeptic Patients and the Influence of Age, Sex, and Helicobacter pylori Infection. Dig Dis Sci 53, 2650–2656 (2008). https://doi.org/10.1007/s10620-007-0177-7

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  • DOI: https://doi.org/10.1007/s10620-007-0177-7

Keywords

  • Peptic ulcer
  • Age
  • Sex
  • H. pylori infection