Digestive Diseases and Sciences

, Volume 52, Issue 10, pp 2707–2715 | Cite as

Paraoxonase (PON)1 192R Allele Carriage is Associated with Reduced Risk of Inflammatory Bowel Disease

  • Amir Karban
  • Corina HartmanEmail author
  • Rami Eliakim
  • Matti Waterman
  • Shula Nesher
  • Ofra Barnett-Griness
  • Raanan Shamir
Original Paper


The paraoxonase (PON) genes family maps to chromosome 7q21-q22, within a loci that also showed evidence of susceptibility genes for both Crohn’s disease (CD) and ulcerative colitis (UC). In this case-control study we investigated the possible relationship between PON1 and PON2 polymorphisms and the risk of inflammatory bowel disease (IBD). PON1 192Q/R, PON1 55L/M, and PON2 311S/C polymorphisms were investigated by RFLP analysis in DNA samples from 224 patients with CD, 58 patients with UC, and 311 healthy controls. The PON1 192R allele was significantly less common among IBD Ashkenazi patients (allelic OR = 0.61, P = 0.004, 95% CI = 0.44–0.85). In agreement with the individual SNP analysis, Ashkenazi IBD patients had a higher frequency of haplotype PON1 192Q/PON1 55L/PON2 311S (26.3% vs 17.3%; P=0.003) and a lower frequency of haplotype PON1 192R/PON1 55L/PON2 311S (18.9% vs 27.7%; P=0.008). Our results suggest that in this Ashkenazi Jewish population, carriage of PON1 R192 allele may confer protection against the development of IBD.


Paraoxonase Lactonase Polymorphism Crohn’s disease Inflammatory bowel disease 



This work was partially supported by Israeli Scientific Foundation Grant No. 373/03-18.1 and a Keren Ezvonot Grant.


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Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Amir Karban
    • 1
  • Corina Hartman
    • 2
    • 4
    Email author
  • Rami Eliakim
    • 1
  • Matti Waterman
    • 1
  • Shula Nesher
    • 1
  • Ofra Barnett-Griness
    • 3
  • Raanan Shamir
    • 2
  1. 1.Department of GastroenterologyRambam Health Care CampusHaifaIsrael
  2. 2.Pediatric Gastroenterology and Nutrition Unit, Meyer Children’s Hospital, Rambam Health Care CampusHaifaIsrael
  3. 3.Department of Community Medicine and EpidemiologyCarmel Medical CenterHaifaIsrael
  4. 4.Division of Pediatric Gastroenterology and NutritionMeyer Children’s Hospital of Haifa, Rambam Health Care CenterHaifaIsrael

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