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Human Pancreatic Digestive Enzymes

Digestive Diseases and Sciences volume 52, pages 1–17 (2007)Cite this article

Abstract

A primary function of the pancreas is to produce digestive enzymes that are delivered to the small intestine for the hydrolysis of complex nutrients. Much of our understanding of digestive enzymes comes from studies in animals. New technologies and the availability of the sequence of the human genome allow for a critical review of older reports and assumptions based on animal studies. This report updates our understanding of human pancreatic digestive enzymes with a focus on new insights into the biology of human proteases, lipases and amylases.

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Authors and Affiliations

  1. Departments of Medicine, Cell Biology and Physiology, and Human Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

    David C. Whitcomb

  2. Pediatrics and Molecular Genetics and Biochemistry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

    Mark E. Lowe

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Whitcomb, D.C., Lowe, M.E. Human Pancreatic Digestive Enzymes. Dig Dis Sci 52, 1–17 (2007). https://doi.org/10.1007/s10620-006-9589-z

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Keywords

  • Trypsin
  • Elastase
  • Lipase
  • Amylase
  • Co-lipase