Digestive Diseases and Sciences

, Volume 51, Issue 12, pp 2154–2159 | Cite as

Electroacupuncture Accelerates Solid Gastric Emptying and Improves Dyspeptic Symptoms in Patients with Functional Dyspepsia

  • Sanping Xu
  • Xiaohua Hou
  • Hui Zha
  • Zhairong Gao
  • Yongxue Zhang
  • J. D. Z. Chen
Original Article

Abstract

The aims of this study were to investigate the effects of electroacupuncture (EA) at ST36 and PC6 points on solid gastric emptying and dyspeptic symptoms in patients with functional dyspepsia. Nineteen patients with functional dyspepsia (FD) were involved in the study, consisting of two parts: (1) acute effects of EA on solid gastric emptying in FD patients with delayed gastric emptying and (2) short-term (2-week) effects of EA on symptoms in FD patients with normal gastric emptying. Results were as follows. (1) Ten of the19 patients showed delayed gastric emptying of solids, and acute EA significantly improved delayed gastric emptying; the halftime for gastric emptying was reduced from 150.3±48.4 to 118.9±29.6 min (P=0.007). (2) In the nine patients with normal gastric emptying, 2-week EA significantly decreased the symptom score, from 8.2±3.3 at baseline to 1.6±1.1 (P < 0.001) at the end of treatment. We conclude that EA at the ST36 and PC6 points accelerates solid gastric emptying in FD patients with delayed gastric emptying and relieves dyspeptic symptoms in FD patients with normal gastric emptying.

Keywords

Acupuncture Functional dyspepsia Gastric emptying Ggastrointestinal motility 

References

  1. 1.
    Lorena SL, Tinois E, Brunetto SQ, Camargo EE, Mesquita MA (2004) Gastric emptying and intragastric distribution of a solid meal in functional dyspepsia: influence of gender and anxiety. J Clin Gastroenterol 38:230–236CrossRefPubMedGoogle Scholar
  2. 2.
    Stanghellini V, De Giorgio R, Barbara G, Cogliandro R, Tosetti C, De Ponti F, Corinaldesi R (2004) Delayed gastric emptying in functional dyspepsia. Curr Treat Options Gastroenterol 7:259–264PubMedGoogle Scholar
  3. 3.
    Nyren O, Adami HO, Gustavsson S, Loof L, Nyberg A (1985) Social and economic effects of non-ulcer dyspepsia. Scand J Gastroenterol 109:41–47Google Scholar
  4. 4.
    Dickerson LM, King DE (2004) Evaluation and management of nonulcer dyspepsia. Am Fam Phys 70:107–114Google Scholar
  5. 5.
    Helms JM (1997) Report on the World Health Organization’s consultation on acupuncture. Med Acupunct 9:44–46Google Scholar
  6. 6.
    Helms JM (1995) Acupuncture energetics: a clinical approach for physicians. Medical Acupuncture, Berkeley, CA, pp 8.123–8.125Google Scholar
  7. 7.
    Sodipo JO, Falaiye JM (1979) Acupuncture and gastric acid studies. Am J Chin Med 7:356–361CrossRefPubMedGoogle Scholar
  8. 8.
    Wu YL, Chen SF, Pan LL (1994) Effect of electroacupuncture on gastric acid secretion and gut hormones. Zhongguo Zhong Xi Yi Jie He Za Zhi 14:709–711PubMedGoogle Scholar
  9. 9.
    Tougas G, Yuan LY, Radamaker JW, Chiverton SG, Hunt RH (1992) Effect of acupuncture on gastric acid secretion in healthy male volunteers. Dig Dis Sci 37:1576–1582CrossRefPubMedGoogle Scholar
  10. 10.
    Lux G, Hagel J, Backer P, Backer G, Vogl R, Ruppin H, Domschke S, Domschke W (1994) Acupuncture inhibits vagal gastric acid secretion stimulated by sham feeding in healthy subjects. Gut 35:1026–1029PubMedGoogle Scholar
  11. 11.
    Shen D, Wei D, Liu B, Zhang F (1995) Effects of electroacupuncture on gastrin, mast cell and gastric mucosal barrier in the course of protecting rat stress peptic ulcer. Zhen Ci Yan Jiu 20:46–49PubMedGoogle Scholar
  12. 12.
    Zhang H, Wan DM, Zhang ZX (1988) The effect and nervous mechanism of acupuncture on gastric blood flow. Zhen Ci Yan Jiu 13:334–349PubMedGoogle Scholar
  13. 13.
    Cheng X (1992) Effect of circadian rhythm on the action of acupuncture to prevent the formation of experimental gastric ulcer. Zhen Ci Yan Jiu 17:117–122PubMedGoogle Scholar
  14. 14.
    Zhou ZL (1991) Clinical research and mechanical inquiry in the treatment of chronic superficial gastritis using ziwuliuzhu day-prescription of acupoints. Zhong Xi Yi Jie He Za Zhi 11:94–96PubMedGoogle Scholar
  15. 15.
    Ouyang H, Yin J, Wang Z, Pasricha PJ, Chen JDZ (2002) Electroacupuncture accelerates gastric emptying in association with changes in vagal activity. Am J Physiol 282:G390–G396Google Scholar
  16. 16.
    Li Y-M, Huang Y-X, Zhang J, Wang Q-L (2001) Effect of electro-acupuncture on gastric emptying of rats treated with ipopolysaccharide and its relationship with serum cytokines Shijie Huaren Xiaohua Zazhi 9:1110–1115Google Scholar
  17. 17.
    Tosetti C, Stanghellini V, Corinaldesi R (2003) The Rome II Criteria for patients with functional gastroduodenal disorders. J Clin Gastroenterol 37:92–93CrossRefPubMedGoogle Scholar
  18. 18.
    Tougas G, Eaker EY, Abell TL, et al. (2000) Assessment of gastric emptying using a low fat meal: establishment of international control values. Am J Gastroenterol 95:1457–1462Google Scholar
  19. 19.
    Lao L, Wong RH, Berman B, Wynn RL (1995) Electroacupuncture reduces morphine-induced emesis in ferrets: a pilot study. J Altern Complement Med 1:257–261PubMedGoogle Scholar
  20. 20.
    Lao L, Zhang G, Wong RH, Carter AK, Wynn RL, Berman BM (2003) The effect of electroacupuncture as an adjunct on cyclophosphamide-induced emesis in ferrets. Pharmacol Biochem Behav 74:691–699CrossRefPubMedGoogle Scholar
  21. 21.
    Coffin B, Azpiroz F, Malagelada J-R (1994) Somatic stimulation reduces erception of gut distention in humans. Gastroenterology 107:1636–1642PubMedGoogle Scholar
  22. 22.
    Ouyang H, Xing J, Yin J, Chen JDZ (2003) Electroacupuncture restores impaired gastric accommodation in vagotomized dogs. Neurogastroenterol Motil 15:635 (abstr)CrossRefGoogle Scholar
  23. 23.
    Zhou L (1986) The regulatory function of acupuncture of the stomach. Zhen Ci Yan Jiu 11:274–279PubMedGoogle Scholar
  24. 24.
    Hu S, Guo Y, Zhang Y, Wang Y, Xu T (1996) Effect of acupuncture on the restrained state of stomach after injecting TFP in Zusanli point. Zhen Ci Yan Jiu 21:57–61PubMedGoogle Scholar
  25. 25.
    Qian LW, Lin YP (1993) Effect of electroacupuncture at zusanli (ST36) point in regulating the pylorus peristaltic function. Zhongguo Zhong Xi Yi Jie He Za Zhi 13:336–339PubMedGoogle Scholar
  26. 26.
    Tatewaki M, Harris M, Uemura K, Ueno T, Hoshino E, Shiotani A, Pappas TN, Takahashi T (2003) Dual effects of acupuncture on gastric motility in conscious rats. Am J Physiol Regul Integr Comp Physiol 285:R862–R872PubMedGoogle Scholar
  27. 27.
    Choi M, Jung J, Seo M, Lee K, Nam T, Yang I, Yoon Y, Yoon J (2001) Ultrasonographic observation of intestinal mobility of dogs after acupunctural stimulation on acupoints ST-36 and BL-27. J Vet Sci 2:221–226PubMedGoogle Scholar
  28. 28.
    Lin X, Liang J, Ren J, Mu F, Zhang M, Chen JD (1997) Electrical stimulation of a cupuncture points enhances gastric myoelectrical activity in humans. Am J Gastroenterol 92:1527–1530PubMedGoogle Scholar
  29. 29.
    Chen JDZ, McCallum RW (1994) Electrogastrographic parameters and their clinical significance. In: Chen JDZ, McCallum RW (eds). Electrogastrography: principles and clinical applications. Raven Press, New York, pp 45–73Google Scholar
  30. 30.
    Chang CS, Ko CW, Wu CY, Chen GH (2001) Effect of electrical stimulation on acupuncture points in diabetic patients with gastric dysrhythmia: a pilot study. Digestion 64:184–190CrossRefPubMedGoogle Scholar
  31. 31.
    Han JS (2003) Acupuncture neuropeptide release produced by electrical stimulation of different frequencies. Trends Neurosci 1:32Google Scholar
  32. 32.
    Chen JDZ, Qian L, Ouyang H, Yin J (2003) Gastric electrical stimulation with short pulses improves vomiting but not gastric dysrhythmia in dogs. Gastroenterology 124:401–409CrossRefPubMedGoogle Scholar
  33. 33.
    Zhang AL, Chen RX, Kang MF, Fan HL, Wang WL (1994) Clinical investigation of acupuncture in the treatment of gastric dysmotility. Chin Acupunct 14:1–3Google Scholar

Copyright information

© Springer Science+Business Media, Inc. 2006

Authors and Affiliations

  • Sanping Xu
    • 1
  • Xiaohua Hou
    • 1
  • Hui Zha
    • 1
  • Zhairong Gao
    • 2
  • Yongxue Zhang
    • 2
  • J. D. Z. Chen
    • 3
  1. 1.Division of Gastroenterology, Union Hospital of Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina
  2. 2.Division of Nuclear Medicine, Union Hospital of Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina
  3. 3.Division of GastroenterologyUniversity of Texas Medical Branch, 221 Microbiology BuildingGalvestonUSA

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